Restoration of N-glycosylation via leucine-activated leucyl-tRNA synthetase 1 overcomes chemoresistance in intrahepatic cholangiocarcinoma
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Background & aims: Intrahepatic cholangiocarcinoma (ICC) is a highly lethal liver malignancy with poor response rates to chemotherapy. Although translational reprogramming is a recognised hallmark of therapy resistance, its role ... ...
