Evidence that MutSβ repairs indels generated by mispair initiated template slippage [0.03%]
MutSβ通过修复由模板滑动引发的错配生成的插入缺失提供证据
Scott A Lujan,Alan B Clark,Jessica S Williams et al.
Scott A Lujan et al.
This study examines the specificity of MutSβ dependent DNA mismatch repair (MMR) at the URA3 reporter gene in Saccharomyces cerevisiae. Addition and deletion mutations containing multiple base changes are observed at elevated rates in msh3...
B cell receptor stimulation inhibits class switch recombination through elevated DNA repair [0.03%]
B细胞受体刺激通过提高DNA修复抑制类别转换重组
Robert W Maul,Rhonda L McFleder,Zheng Cao et al.
Robert W Maul et al.
Antibody diversity in B cells arises from the activity of activation-induced deaminase (AID), which introduces uracils into DNA of the immunoglobulin loci. The presence of uracil initiates a cascade of mutagenic events, resulting in somatic...
Alexander V Mazin,Andrei Kuzminov,Murat Saparbaev et al.
Alexander V Mazin et al.
Penny Jeggo,Puck Knipscheer,Peter J McHugh
Penny Jeggo
DNA Repair Special Issue: Genome maintenance pathways in cancer - etiology, biomarkers and targets [0.03%]
DNA修复专题：癌症中的基因组维护途径-病因学、生物标志物和靶点
Robert W Sobol,Gianluca Tell
Robert W Sobol
Dss1 facilitates Rad51 recruitment downstream of BRCA2/Brh2 in response to DNA damage [0.03%]
DNA损伤时BRCA2／Brh2的下游Dss1促进Rad51募集反应
Louise Juhl,Linea Busch,Jonas Bagge et al.
Louise Juhl et al.
Homologous recombination (HR) is a major pathway for repair of DNA double-strand breaks (DSB), recovery of broken replication forks and formation of meiotic crossovers. HR provides a mechanism to precisely repair damaged DNA in a template-d...
Guo-Min Li,Zhao-Qi Wang
Guo-Min Li
Jochen Kuper,Caroline Kisker
Jochen Kuper
Nucleotide excison repair (NER) is a highly versatile template-based DNA repair mechanism that can address lesions ranging from cyclo butane pyrimdine dimers, to cisplatinum crosslinks, and bulky adducts like acetyl amino flourenes. Eukaryo...
Penny Jeggo
Penny Jeggo
Efficient activity of uracil DNA glycosylase (UNG2) in proliferating cells requires binding to proliferating cell nuclear antigen (PCNA) and replication protein A (RPA) [0.03%]
尿嘧啶DNA糖基化酶(UNG2)在增殖细胞中的有效活性依赖于与增殖细胞核抗原(PCNA)和复制蛋白A(RPA)的结合
Rashmi S Kulkarni,Brian P Weiser
Rashmi S Kulkarni
The compounds pemetrexed and 5-fluorodeoxyuridine (FdU) are widely used for cancer therapies and disrupt cell proliferation by inducing DNA damage and stressing DNA replication. The drugs disrupt pyrimidine nucleotide metabolism and promote...