Tissue-specific CTG•CAG expansion rate and disease severity are modified by DNA repair genes expression levels in myotonic dystrophy type 1 patients [0.03%]
DM1患者中组织特异性CTG•CAG重复序列的扩增速率和疾病严重程度受DNA修复基因表达水平的影响
Melissa Palma-Jiménez,Lisbeth Ramirez-Carvajal,Hailey Olafson et al.
Melissa Palma-Jiménez et al.
Myotonic dystrophy type 1 (DM1) is a multisystemic autosomal dominant disorder caused by the expansion of an unstable CTG•CAG repeat in the DMPK gene. This study examined whether differential expression of DNA repair genes in three differe...
Molecular mechanisms of DNA damage recognition and chromatin dynamics regulating mammalian nucleotide excision repair [0.03%]
哺乳动物核苷酸切除修复过程中DNA损伤识别及染色质动态变化的分子机制研究
Masayuki Kusakabe,Kaoru Sugasawa
Masayuki Kusakabe
Nucleotide excision repair (NER) is a principal DNA repair system that can remove a wide variety of DNA lesions caused mainly by environmental agents such as ultraviolet irradiation and chemical compounds. In global genome NER (GG-NER) of h...
The nuclear structural protein NuMA is required for efficient DNA replication and supports the association of core replication factors to replication forks [0.03%]
核结构蛋白NuMA是有效DNA复制所必需的，并支持核心复制因子与复制叉结合
Zhen-Guo Wang,Sara Knowles,Fang Wang et al.
Zhen-Guo Wang et al.
DNA replication is a strictly regulated process during cell proliferation to ensure faithful duplication of the genome. Its firing and elongation can be arrested or temporally inhibited in response to a variety of internal and external caus...
Editors' Note [0.03%]
编者按
Penny Jeggo,Bennett Van Houten
Penny Jeggo
Nuclear receptor co-activator 4 interacts with RUVBL1/2 to maintain genome integrity through double-strand break repair [0.03%]
核受体辅激活因子4通过与RUVBL1/2相互作用维持DNA双链断裂修复以保持基因组稳定性
Yingying Chen,Qi Zhang,Zongjian Tao et al.
Yingying Chen et al.
DNA double-strand breaks (DSBs) are among the most cytotoxic forms of chromosomal lesions and are primarily repaired through homologous recombination (HR) or non-homologous end joining (NHEJ). The precise repair of DSBs via HR necessitates ...
DNA-repair and transcriptional defects drive hematologic malignancies in xeroderma pigmentosum group C patients: A new hypothesis [0.03%]
DNA修复和转录缺陷驱动着色素性干皮病C组患者的血液系统恶性肿瘤：一种新的假说
Alain Sarasin
Alain Sarasin
Xeroderma pigmentosum (XP) is a rare recessive autosomal genodermatosis caused by defects in nucleotide excision repair (NER). Patients with XP are extremely sensitive to ultraviolet-light, resulting in an increased incidence of skin cancer...
XPC and global genome nucleotide excision repair are essential for telomere stability after UVC-induced DNA damage in human cells [0.03%]
XPC和全球基因组核苷酸切除修复在紫外线照射后的人类细胞端粒稳定性中起关键作用
Ariana Detwiler,Adam Barsouk,Mariarosaria De Rosa et al.
Ariana Detwiler et al.
Telomeric sequences are hotspots for ultraviolet light (UV) induced cyclobutane pyrimidine dimers (CPD) and pyrimidine(6-4)pyrimidone photoproducts (6-4 PP), due to pyrimidine runs on both the TTAGGG and CCCTAA containing strands. Photoprod...
MLH1 silencing reprograms PI3K/AKT and JAK/STAT signaling to enhance 5-Fluorouracil sensitivity in colorectal cancer cells [0.03%]
MLH1沉默通过重新编程PI3K / AKT和JAK / STAT信号传导来增强结直肠癌细胞对5-氟尿嘧啶的敏感性
Hali̇me Topal Kızıloğlu,Adem Kara
Hali̇me Topal Kızıloğlu
Background/aim: This study aimed to evaluate the anticancer efficacy of 5-Fluorouracil (5-FU) in Caco-2 human colorectal adenocarcinoma cells treated with siRNA-mediated MLH1 gene inhibition, in terms of cell viability, a...
From DNA repair to neurodegeneration: PARP1 mechanisms and inhibitor strategies in Alzheimer's disease [0.03%]
从DNA修复到神经退行性病变：PARP1在阿尔茨海默病中的机制与抑制策略
Purusottam Banjare,Richa Patel
Purusottam Banjare
PARP1 is a key regulator of DNA damage responses. Reports from cell and animal models suggest that when excessively active, PARP1 exacerbates oxidative stress, mitochondrial dysfunction, and neuroinflammation, which are indicative of Alzhei...
Caulobacter crescentus harbours an evolutionarily distinct UDG (CC2084), UdgC, sharing features with family I and family V UDGs [0.03%]
Caulobacter crescentus 中存在一种进化上独特的尿嘧啶-DNA糖基化酶（UDG，CC2084），UdgC，它同时具有I族和V族UDGs的特征
Koyel Roy,Elhassan Ali Fathi Emam,Shruti Sharma et al.
Koyel Roy et al.
Uracil arises in DNA either by spontaneous deamination of cytosine or misincorporation of dUMP by DNA polymerases. Cytosine deamination (to uracil), if unrepaired, may lead to GC to AT mutation. Uracil DNA glycosylases (UDGs) initiate the b...