Alexander V Mazin,Andrei Kuzminov,Murat Saparbaev et al.
Alexander V Mazin et al.
Penny Jeggo,Puck Knipscheer,Peter J McHugh
Penny Jeggo
DNA Repair Special Issue: Genome maintenance pathways in cancer - etiology, biomarkers and targets [0.03%]
DNA修复专题：癌症中的基因组维护途径-病因学、生物标志物和靶点
Robert W Sobol,Gianluca Tell
Robert W Sobol
Dss1 facilitates Rad51 recruitment downstream of BRCA2/Brh2 in response to DNA damage [0.03%]
DNA损伤时BRCA2／Brh2的下游Dss1促进Rad51募集反应
Louise Juhl,Linea Busch,Jonas Bagge et al.
Louise Juhl et al.
Homologous recombination (HR) is a major pathway for repair of DNA double-strand breaks (DSB), recovery of broken replication forks and formation of meiotic crossovers. HR provides a mechanism to precisely repair damaged DNA in a template-d...
Guo-Min Li,Zhao-Qi Wang
Guo-Min Li
Jochen Kuper,Caroline Kisker
Jochen Kuper
Nucleotide excison repair (NER) is a highly versatile template-based DNA repair mechanism that can address lesions ranging from cyclo butane pyrimdine dimers, to cisplatinum crosslinks, and bulky adducts like acetyl amino flourenes. Eukaryo...
Penny Jeggo
Penny Jeggo
Efficient activity of uracil DNA glycosylase (UNG2) in proliferating cells requires binding to proliferating cell nuclear antigen (PCNA) and replication protein A (RPA) [0.03%]
尿嘧啶DNA糖基化酶(UNG2)在增殖细胞中的有效活性依赖于与增殖细胞核抗原(PCNA)和复制蛋白A(RPA)的结合
Rashmi S Kulkarni,Brian P Weiser
Rashmi S Kulkarni
The compounds pemetrexed and 5-fluorodeoxyuridine (FdU) are widely used for cancer therapies and disrupt cell proliferation by inducing DNA damage and stressing DNA replication. The drugs disrupt pyrimidine nucleotide metabolism and promote...
Genetic analysis reveals a timing-dependent functional interplay between Polζ and Polη in translesion DNA synthesis upon UV damage [0.03%]
遗传分析揭示了在紫外线损伤后Polζ和Polη在跨损伤DNA合成中的功能相互作用取决于时间因素
Mone Okuda,Minori Fujii,Ryotaro Kawasumi et al.
Mone Okuda et al.
Translesion DNA synthesis (TLS) plays a crucial role in restarting stalled replication at damaged templates. This process is facilitated by specialized DNA polymerases, such as Polη and Polζ, where Polη inserts nucleotides opposite the d...
Chelsea M Smith,Gaorav P Gupta
Chelsea M Smith
DNA Polymerase theta (Polθ, gene name POLQ) is the central enzyme of theta-mediated end-joining (TMEJ), an intrinsically mutagenic DNA double-strand break (DSB) repair pathway. Polθ is broadly conserved across most metazoan and plant spec...