Navigating nuclear space: How Rad51 filaments promote long-range homology search during homologous recombination - Lessons from budding yeast [0.03%]
核定位的奥秘：Rad51丝状体在同源重组时促进远程寻靶的分子机制——从酿酒酵母得到的启示
Fadma Lakhal,Angela Taddei
Fadma Lakhal
DNA double-strand breaks (DSBs) threaten genomic integrity, with erroneous repair leading to chromosomal rearrangements and pathologies. In eukaryotes, DSBs are primarily repaired via non-homologous end-joining (NHEJ) or homologous recombin...
Sex and base excision repair as key susceptibility factors for alkylation-induced mutations, toxicity and hepatic cancer [0.03%]
性别和碱基切除修复是烷基诱导的突变、毒性和肝癌的关键易感因素
Jennifer E Kay,Joshua J Corrigan,Lindsay B Volk et al.
Jennifer E Kay et al.
N-Nitrosodimethylamine (NDMA) is present in food, water, and drugs and is considered a probable human carcinogen by the International Agency for Research on Cancer. The mechanism of action of NDMA involves the generation of carcinogenic met...
NEK3 promotes cancer resistance through facilitating CtIP-mediated DNA repair [0.03%]
NEK3通过促进CtIP介导的DNA修复来促进癌症耐药性
Yan Zhang,Qingqiu Wen,Haibo Huang et al.
Yan Zhang et al.
DNA double-strand breaks (DSBs) are the most harmful type of DNA damage. Efficient repair of DSBs is critical for cell survival and contributes to cancer resistance. Protein kinases have been found to be involved in this sophisticated proce...
PARP1 safeguards nascent DNA from SMUG1-dependent processing of incorporated 5-hydroxymethyl-2'-deoxyuridine [0.03%]
PARP1通过防止SMUG1依赖性加工保护新生DNA中的5-羟甲基脱氧尿苷的掺入
Rubaiat E Tabassum,Kouji Hirota,Ryotaro Kawasumi
Rubaiat E Tabassum
DNA base damage is the most common form of lesion, occurring approximately 10,000 times per cell a day. Such damage arises either from the incorporation of damaged nucleotides or from direct modification of bases within DNA strand. 5-hydrox...
Tissue-specific CTG•CAG expansion rate and disease severity are modified by DNA repair genes expression levels in myotonic dystrophy type 1 patients [0.03%]
DM1患者中组织特异性CTG•CAG重复序列的扩增速率和疾病严重程度受DNA修复基因表达水平的影响
Melissa Palma-Jiménez,Lisbeth Ramirez-Carvajal,Hailey Olafson et al.
Melissa Palma-Jiménez et al.
Myotonic dystrophy type 1 (DM1) is a multisystemic autosomal dominant disorder caused by the expansion of an unstable CTG•CAG repeat in the DMPK gene. This study examined whether differential expression of DNA repair genes in three differe...
Molecular mechanisms of DNA damage recognition and chromatin dynamics regulating mammalian nucleotide excision repair [0.03%]
哺乳动物核苷酸切除修复过程中DNA损伤识别及染色质动态变化的分子机制研究
Masayuki Kusakabe,Kaoru Sugasawa
Masayuki Kusakabe
Nucleotide excision repair (NER) is a principal DNA repair system that can remove a wide variety of DNA lesions caused mainly by environmental agents such as ultraviolet irradiation and chemical compounds. In global genome NER (GG-NER) of h...
The nuclear structural protein NuMA is required for efficient DNA replication and supports the association of core replication factors to replication forks [0.03%]
核结构蛋白NuMA是有效DNA复制所必需的，并支持核心复制因子与复制叉结合
Zhen-Guo Wang,Sara Knowles,Fang Wang et al.
Zhen-Guo Wang et al.
DNA replication is a strictly regulated process during cell proliferation to ensure faithful duplication of the genome. Its firing and elongation can be arrested or temporally inhibited in response to a variety of internal and external caus...
Editors' Note [0.03%]
编者按
Penny Jeggo,Bennett Van Houten
Penny Jeggo
Nuclear receptor co-activator 4 interacts with RUVBL1/2 to maintain genome integrity through double-strand break repair [0.03%]
核受体辅激活因子4通过与RUVBL1/2相互作用维持DNA双链断裂修复以保持基因组稳定性
Yingying Chen,Qi Zhang,Zongjian Tao et al.
Yingying Chen et al.
DNA double-strand breaks (DSBs) are among the most cytotoxic forms of chromosomal lesions and are primarily repaired through homologous recombination (HR) or non-homologous end joining (NHEJ). The precise repair of DSBs via HR necessitates ...
DNA-repair and transcriptional defects drive hematologic malignancies in xeroderma pigmentosum group C patients: A new hypothesis [0.03%]
DNA修复和转录缺陷驱动着色素性干皮病C组患者的血液系统恶性肿瘤：一种新的假说
Alain Sarasin
Alain Sarasin
Xeroderma pigmentosum (XP) is a rare recessive autosomal genodermatosis caused by defects in nucleotide excision repair (NER). Patients with XP are extremely sensitive to ultraviolet-light, resulting in an increased incidence of skin cancer...