MLH1 silencing reprograms PI3K/AKT and JAK/STAT signaling to enhance 5-Fluorouracil sensitivity in colorectal cancer cells [0.03%]
MLH1沉默通过重新编程PI3K / AKT和JAK / STAT信号传导来增强结直肠癌细胞对5-氟尿嘧啶的敏感性
Hali̇me Topal Kızıloğlu,Adem Kara
Hali̇me Topal Kızıloğlu
Background/aim: This study aimed to evaluate the anticancer efficacy of 5-Fluorouracil (5-FU) in Caco-2 human colorectal adenocarcinoma cells treated with siRNA-mediated MLH1 gene inhibition, in terms of cell viability, a...
From DNA repair to neurodegeneration: PARP1 mechanisms and inhibitor strategies in Alzheimer's disease [0.03%]
从DNA修复到神经退行性病变：PARP1在阿尔茨海默病中的机制与抑制策略
Purusottam Banjare,Richa Patel
Purusottam Banjare
PARP1 is a key regulator of DNA damage responses. Reports from cell and animal models suggest that when excessively active, PARP1 exacerbates oxidative stress, mitochondrial dysfunction, and neuroinflammation, which are indicative of Alzhei...
Caulobacter crescentus harbours an evolutionarily distinct UDG (CC2084), UdgC, sharing features with family I and family V UDGs [0.03%]
Caulobacter crescentus 中存在一种进化上独特的尿嘧啶-DNA糖基化酶（UDG，CC2084），UdgC，它同时具有I族和V族UDGs的特征
Koyel Roy,Elhassan Ali Fathi Emam,Shruti Sharma et al.
Koyel Roy et al.
Uracil arises in DNA either by spontaneous deamination of cytosine or misincorporation of dUMP by DNA polymerases. Cytosine deamination (to uracil), if unrepaired, may lead to GC to AT mutation. Uracil DNA glycosylases (UDGs) initiate the b...
Rtt107 cooperates with Rad55 to limit specific types of genome instability in Saccharomyces cerevisiae [0.03%]
酿酒酵母中的Rtt107通过与Rad55的相互作用限制特定类型的基因组不稳定现象
Joshua A R Brown,Hilary T Brewis,Michael S Kobor
Joshua A R Brown
A range of genome maintenance factors respond to endogenous and exogenous DNA damage to prevent mutations and cell death. The scaffold protein, Rtt107, is important for the growth of cells exposed to DNA-damaging agents in the budding yeast...
An antimorphic mutant of Brh2 resulting from a conservative amino acid change within the BRC element [0.03%]
Brc元件内的保守氨基酸变化导致的Brh2反形态突变体
Jeanette H Sutherland,Gary E Xavier Valdez,William K Holloman
Jeanette H Sutherland
Brh2, the streamlined BRCA2 family protein from Ustilago maydis, directs homologous recombination by modulating Rad51 filament dynamics through a single BRC element. Here, we describe an unusual antimorphic mutation within the BRC β-hairpi...
Activation of Escherichia coli RecA* in recA730 lexA+ and recA730 lexA(Def) strain backgrounds [0.03%]
在recA730 lexA(+)和recA730 lexA(Def)菌株背景下激活Escherichia coli RecA*
John P McDonald,Jaan C Selod,Marcela Teatin Latancia et al.
John P McDonald et al.
The Escherichia coli RecA protein plays central roles in mediating homologous recombination, induction of the damage inducible SOS response and cellular mutagenesis. All three roles require that monomeric RecA assembles on single-stranded D...
Dorota Dziuban-Lech,Agata Lipko,Andria R Robinson et al.
Dorota Dziuban-Lech et al.
Mutations in the Ercc1 gene, essential for DNA repair, are associated with accelerated aging and metabolic disturbances, but data on lipid composition under its deficiency remain limited. To address this gap, we analyzed the fatty acid (FA)...
Single-cell transcriptomics reveal PRRC1 as a malignant cell enriched driver of DNA repair and therapy resistance in glioblastoma [0.03%]
单细胞测序揭示GBM中富集于恶性细胞的DNA修复和耐药驱动因子PRRC1
Sachin Kumar,Ming-Cheng Tsai,Dahlak Daniel Solomon et al.
Sachin Kumar et al.
Glioblastoma (GBM) is the most aggressive primary brain tumor and remains largely refractory to radiotherapy and temozolomide-based therapy. Although these treatments induce DNA damage, GBM cells frequently survive by activating DNA damage ...
Richard Gatti: From concert pianist to bone marrow transplants and the DNA damage response syndrome, ataxia-telangiectasia [0.03%]
理查德·加蒂：从音乐会钢琴家到骨髓移植和DNA损伤反应综合征，共济失调-毛细血管扩张症
Martin Lavin,A M R Taylor,Yosef Shiloh
Martin Lavin
Sgs1 and Esc2 suppress chromosome translocations induced by a replication fork barrier in Saccharomyces cerevisiae [0.03%]
Sgs1和Esc2通过抑制Saccharomyces cerevisiae中由复制叉屏障诱导的染色体易位发挥功能
Léa Marie,Marina K Triplett,Iffat Ahmed et al.
Léa Marie et al.
Replication stress is recognized as a major cause of genomic instability in eukaryotes and is associated with various human pathologies, including cancer. To investigate the mechanisms driving gross chromosomal rearrangements in response to...