Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation [0.03%]
线粒体细胞色素c核转位通过改变核糖体液-液相分离释放与核仁结合蛋白NPM1结合的肿瘤抑制因子ARF
Katiuska González-Arzola,Antonio Díaz-Quintana,Noelia Bernardo-García et al.
Katiuska González-Arzola et al.
The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet cytochrome c (Cc) migrates to the nucleus and even the nucleolus under stress conditions. Nucleolar liquid-liquid phase sepa...
A quick fix for lysosomes [0.03%]
细胞溶酶体快速修复方案
Katharine H Wrighton
Katharine H Wrighton
Joseph Willson
Joseph Willson
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction [0.03%]
PKA抑制基序通过SMO控制Hh信号转导
John T Happ,Corvin D Arveseth,Jessica Bruystens et al.
John T Happ et al.
The Hedgehog (Hh) cascade is central to development, tissue homeostasis and cancer. A pivotal step in Hh signal transduction is the activation of glioma-associated (GLI) transcription factors by the atypical G protein-coupled receptor (GPCR...
Sara Osman
Sara Osman
SHOCing RAF into action [0.03%]
促使英国皇家空军采取行动
Helen R Mott,Darerca Owen
Helen R Mott
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome [0.03%]
SHOC2-MRAS-PP1C复合物的结构为RAF激活及Noonan综合征提供了新的见解
Daniel A Bonsor,Patrick Alexander,Kelly Snead et al.
Daniel A Bonsor et al.
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephospho...
Compartmentalization of the replication fork by single-stranded DNA-binding protein regulates translesion synthesis [0.03%]
单链DNA结合蛋白对复制叉的区室化调控跨损伤合成修复
Seungwoo Chang,Elizabeth S Thrall,Luisa Laureti et al.
Seungwoo Chang et al.
Processivity clamps tether DNA polymerases to DNA, allowing their access to the primer-template junction. In addition to DNA replication, DNA polymerases also participate in various genome maintenance activities, including translesion synth...