Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome
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SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific ... ...
