Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport [0.03%]
微管结合诱导的变构触发LIS1在运载之前脱离动力蛋白
William D Ton,Yue Wang,Pengxin Chai et al.
William D Ton et al.
The lissencephaly-related protein LIS1 is a critical regulator of cytoplasmic dynein that governs motor function and intracellular localization (for example, to microtubule plus-ends). Although LIS1 binding is required for dynein activity, ...
Carlos Lopez-Robles,Stefano Scaramuzza,Elsa N Astorga-Simon et al.
Carlos Lopez-Robles et al.
Recycling of membrane proteins enables the reuse of receptors, ion channels and transporters. A key component of the recycling machinery is the endosomal sorting complex for promoting exit 1 (ESCPE-1), which rescues transmembrane proteins f...
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function [0.03%]
组蛋白H4K16乙酰化激活转座元件的转录并促进其顺式调控功能
Debosree Pal,Manthan Patel,Fanny Boulet et al.
Debosree Pal et al.
Mammalian genomes harbor abundant transposable elements (TEs) and their remnants, with numerous epigenetic repression mechanisms enacted to silence TE transcription. However, TEs are upregulated during early development, neuronal lineage, a...
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization [0.03%]
RNA聚合酶II从失活X染色体区的丢失并非由物理隔室化介导
Samuel Collombet,Isabell Rall,Claire Dugast-Darzacq et al.
Samuel Collombet et al.
Subnuclear compartmentalization has been proposed to play an important role in gene regulation by segregating active and inactive parts of the genome in distinct physical and biochemical environments. During X chromosome inactivation (XCI),...
Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2-p53 pathways [0.03%]
新生5S RNPs在核糖体装配和MDM2-p53通路之间的结构
Nestor Miguel Castillo Duque de Estrada,Matthias Thoms,Dirk Flemming et al.
Nestor Miguel Castillo Duque de Estrada et al.
The 5S ribonucleoprotein (RNP) is assembled from its three components (5S rRNA, Rpl5/uL18 and Rpl11/uL5) before being incorporated into the pre-60S subunit. However, when ribosome synthesis is disturbed, a free 5S RNP can enter the MDM2-p53...
Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2 [0.03%]
OCT1和OCT2多药与外源性物质识别的分子机制研究
Yang Suo,Nicholas J Wright,Hugo Guterres et al.
Yang Suo et al.
A wide range of endogenous and xenobiotic organic ions require facilitated transport systems to cross the plasma membrane for their disposition. In mammals, organic cation transporter (OCT) subtypes 1 and 2 (OCT1 and OCT2, also known as SLC...
Fighting pain: the structure of gabapentin and its binding site in the Cavα2δ subunit [0.03%]
抗痛：加巴喷丁的结构及其与CaVα2δ亚基结合位点的结构
Laurent Ferron,Maria A Gandini,Gerald W Zamponi
Laurent Ferron
Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand [0.03%]
调节细菌RNA聚合酶暂停的核糖开关及其配基的结构基础
Adrien Chauvier,Jason C Porta,Indrajit Deb et al.
Adrien Chauvier et al.
Folding of nascent transcripts can be modulated by the RNA polymerase (RNAP) that carries out their transcription, and vice versa. A pause of RNAP during transcription of a preQ1 riboswitch (termed que-PEC) is stabilized by a previously cha...