Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport
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The lissencephaly-related protein LIS1 is a critical regulator of cytoplasmic dynein that governs motor function and intracellular localization (for example, to microtubule plus-ends). Although LIS1 binding is required for dynein activity, its unbinding prior ... ...
