Jie Yang,Kelsey R Baron,Daniel E Pride et al.
Jie Yang et al.
Mitochondria are dynamic organelles that continually respond to cellular stress. Recent studies have demonstrated that mitochondrial stress is relayed from mitochondria to the cytosol by the release of a proteolytic fragment of DELE1 that b...
Helge Paternoga,Caillan Crowe-McAuliffe,Lars V Bock et al.
Helge Paternoga et al.
The ribosome is a major target for clinically used antibiotics, but multidrug resistant pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we present cryo-electron-microscopy structures of 17 distinct compou...
The structure of the NuA4-Tip60 complex reveals the mechanism and importance of long-range chromatin modification [0.03%]
NuA4-Tip60复合物的结构揭示了远距离染色质修饰的重要性和机理
Alexander Fréchard,Céline Faux,Rozalie Hexnerova et al.
Alexander Fréchard et al.
Histone acetylation regulates most DNA transactions and is dynamically controlled by highly conserved enzymes. The only essential histone acetyltransferase (HAT) in yeast, Esa1, is part of the 1-MDa NuA4 complex, which plays pivotal roles i...
Alan C M Cheung
Alan C M Cheung
Transcription modulates chromatin dynamics and locus configuration sampling [0.03%]
转录调控染色质动力学和位点构象取样
Giada Forte,Adam Buckle,Shelagh Boyle et al.
Giada Forte et al.
In living cells, the 3D structure of gene loci is dynamic, but this is not revealed by 3C and FISH experiments in fixed samples, leaving a notable gap in our understanding. To overcome these limitations, we applied the highly predictive het...
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals [0.03%]
精细调控的平衡术——表转录组调节哺乳动物剂量补偿机制的作用原理
Joanna W Jachowicz
Joanna W Jachowicz
Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2 [0.03%]
BIRC2蛋白胞核积累及其定位的分子机制研究
Adam H Tencer,Yucong Yu,Sebastien Z Causse et al.
Adam H Tencer et al.
The inhibitor of apoptosis protein BIRC2 regulates fundamental cell death and survival signaling pathways. Here we show that BIRC2 accumulates in the nucleus via binding of its second and third BIR domains, BIRC2BIR2 and BIRC2BIR3, to the h...
RNA polymerase II pausing regulates chromatin organization in erythrocytes [0.03%]
RNA聚合酶II暂停调控红细胞染色质的组织方式
Andrés Penagos-Puig,Sherlyn Claudio-Galeana,Aura Stephenson-Gussinye et al.
Andrés Penagos-Puig et al.
Chicken erythrocytes are nucleated cells often considered to be transcriptionally inactive, although the epigenetic changes and chromatin remodeling that would mediate transcriptional repression and the extent of gene silencing during avian...
Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities [0.03%]
组蛋白去乙酰化酶1和组蛋白去乙酰化酶2之间的旁自杀性作用可利用NuRD复合体在癌症中的特异性易感性
Yuxiang Zhang,David Remillard,Ugoma Onubogu et al.
Yuxiang Zhang et al.
Transcriptional co-regulators have been widely pursued as targets for disrupting oncogenic gene regulatory programs. However, many proteins in this target class are universally essential for cell survival, which limits their therapeutic win...