Modulation of GluA2-γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2 [0.03%]
辅助亚基cornichon-2对GluA2-γ5突触复合体脱敏、多胺阻滞和抗癫痫药物perampanel抑制的调节作用
Shanti Pal Gangwar,Laura Y Yen,Maria V Yelshanskaya et al.
Shanti Pal Gangwar et al.
Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and can be targeted to treat neuropsychiatric and neurological disorders...
All roads lead to MRN regulation at telomeres: different paths to one solution [0.03%]
条条道路通MRN：通向端粒的多种路径及相同解决方案
Florian Roisné-Hamelin,Stéphane Marcand
Florian Roisné-Hamelin
DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres [0.03%]
DNA-PK和TRF2介导的iDDR抑制MRN启动的端粒降解反应
Logan R Myler,Beatrice Toia,Cara K Vaughan et al.
Logan R Myler et al.
Telomeres replicated by leading-strand synthesis lack the 3' overhang required for telomere protection. Surprisingly, resection of these blunt telomeres is initiated by the telomere-specific 5' exonuclease Apollo rather than the Mre11-Rad50...
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants [0.03%]
激发态活性K-Ras的观测揭示了野生型与致癌G12D和G12C突变体的不同结构动力学
Alexandar L Hansen,Xinyao Xiang,Chunhua Yuan et al.
Alexandar L Hansen et al.
Despite the prominent role of the K-Ras protein in many different types of human cancer, major gaps in atomic-level information severely limit our understanding of its functions in health and disease. Here, we report the quantitative backbo...
Margherita M Botto,Alessandro Borsellini,Meindert H Lamers
Margherita M Botto
DNA replication introduces thousands of RNA primers into the lagging strand that need to be removed for replication to be completed. In Escherichia coli when the replicative DNA polymerase Pol IIIα terminates at a previously synthesized RN...
Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge [0.03%]
Lis1通过充当分子楔来解除细胞质动力蛋白-1的自我抑制作用
Eva P Karasmanis,Janice M Reimer,Agnieszka A Kendrick et al.
Eva P Karasmanis et al.
Cytoplasmic dynein-1 transports intracellular cargo towards microtubule minus ends. Dynein is autoinhibited and undergoes conformational changes to form an active complex that consists of one or two dynein dimers, the dynactin complex, and ...
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization [0.03%]
使HIV-1 V3环呈螺旋构象以实现广泛中和能力
Matthias Glögl,Nikolas Friedrich,Gabriele Cerutti et al.
Matthias Glögl et al.
The third variable (V3) loop on the human immunodeficiency virus 1 (HIV-1) envelope glycoprotein trimer is indispensable for virus cell entry. Conformational masking of V3 within the trimer allows efficient neutralization via V3 only by rar...