DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres
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Telomeres replicated by leading-strand synthesis lack the 3' overhang required for telomere protection. Surprisingly, resection of these blunt telomeres is initiated by the telomere-specific 5' exonuclease Apollo rather than the Mre11-Rad50-Nbs1 (MRN) complex,... ...
