Marcel A T M van Vugt,Marcel Tijsterman
Marcel A T M van Vugt
Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism [0.03%]
增值信号依赖的RNA代谢中的启动子内转录起始位点切换
Joseph W Wragg,Paige-Louise White,Yavor Hadzhiev et al.
Joseph W Wragg et al.
Global changes in transcriptional regulation and RNA metabolism are crucial features of cancer development. However, little is known about the role of the core promoter in defining transcript identity and post-transcriptional fates, a poten...
Author Correction: In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search [0.03%]
作者更正：体内追踪功能标记Rad51揭示了同源搜索的稳健策略
Siyu Liu,Judith Miné-Hattab,Marie Villemeur et al.
Siyu Liu et al.
Published Erratum
Nature structural & molecular biology. 2023 Dec;30(12):2020. DOI:10.1038/s41594-023-01180-8 2023
Laura Sala,Manish Kumar,Mahendra Prajapat et al.
Laura Sala et al.
Argonaute 2 (AGO2) is a cytoplasmic component of the miRNA pathway, with essential roles in development and disease. Yet little is known about its regulation in vivo. Here we show that in quiescent mouse splenocytes, AGO2 localizes almost e...
Haoxi Wu,Luka Smalinskaitė,Ramanujan S Hegde
Haoxi Wu
Most eukaryotic multipass membrane proteins are inserted into the membrane of the endoplasmic reticulum. Their transmembrane domains (TMDs) are thought to be inserted co-translationally as they emerge from a membrane-bound ribosome. Here we...
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation [0.03%]
结合化学和遗传筛选揭示FSP1调控铁死亡机制
Toshitaka Nakamura,Eikan Mishima,Naoya Yamada et al.
Toshitaka Nakamura et al.
Ferroptosis, marked by iron-dependent lipid peroxidation, may present an Achilles heel for the treatment of cancers. Ferroptosis suppressor protein-1 (FSP1), as the second ferroptosis mainstay, efficiently prevents lipid peroxidation via NA...
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation [0.03%]
起始密码子相关核糖体框移调节营养应激适应性
Yuanhui Mao,Longfei Jia,Leiming Dong et al.
Yuanhui Mao et al.
A translating ribosome is typically thought to follow the reading frame defined by the selected start codon. Using super-resolution ribosome profiling, here we report pervasive out-of-frame translation immediately from the start codon. Star...
Christina M Bebber,Silvia von Karstedt
Christina M Bebber