Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBPα [0.03%]
PU.1和C / EBPα通过CX3CR1核小体协同定位的结构机制
Tengfei Lian,Ruifang Guan,Bing-Rui Zhou et al.
Tengfei Lian et al.
Pioneer transcription factors are vital for cell fate changes. PU.1 and C/EBPα work together to regulate hematopoietic stem cell differentiation. However, how they recognize in vivo nucleosomal DNA targets remains elusive. Here we report t...
Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament [0.03%]
Cortactin通过将激活的Arp2/3连接到其核化的肌动蛋白丝来稳定肌动蛋白分支
Tianyang Liu,Luyan Cao,Miroslav Mladenov et al.
Tianyang Liu et al.
Regulation of the assembly and turnover of branched actin filament networks nucleated by the Arp2/3 complex is essential during many cellular processes, including cell migration and membrane trafficking. Cortactin is important for actin bra...
Peter D Mabbitt
Peter D Mabbitt
Thinking outside the chromosome: epigenetic mechanisms in non-canonical chromatin species [0.03%]
染色体以外的思考：非典型染色质种类中的表观遗传机制
Albert S Agustinus,Yael David
Albert S Agustinus
Here we investigate the role of epigenetics in the formation, transcription regulation, maintenance and termination of several non-canonical chromatin structures. Using two examples, we demonstrate how studying non-canonical structures may ...
Martyn David Winn
Martyn David Winn
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos [0.03%]
谱系调节因子TFAP2C和NR5A2在全能胚胎中作为双潜能激活子的功能
Lijia Li,Fangnong Lai,Ling Liu et al.
Lijia Li et al.
During the first lineage segregation, a mammalian totipotent embryo differentiates into the inner cell mass (ICM) and trophectoderm (TE). However, how transcription factors (TFs) regulate this earliest cell-fate decision in vivo remains elu...
The histone chaperone SPT2 regulates chromatin structure and function in Metazoa [0.03%]
组蛋白分子伴侣SPT2在Metazoa中调控染色质的结构和功能
Giulia Saredi,Francesco N Carelli,Stéphane G M Rolland et al.
Giulia Saredi et al.
Histone chaperones control nucleosome density and chromatin structure. In yeast, the H3-H4 chaperone Spt2 controls histone deposition at active genes but its roles in metazoan chromatin structure and organismal physiology are not known. Her...
Jinta Asami,Jae-Hyun Park,Yayoi Nomura et al.
Jinta Asami et al.
Hepatitis B virus (HBV), a leading cause of developing hepatocellular carcinoma affecting more than 290 million people worldwide, is an enveloped DNA virus specifically infecting hepatocytes. Myristoylated preS1 domain of the HBV large surf...
Sergei Pourmal,Evan Green,Ruchika Bajaj et al.
Sergei Pourmal et al.
Multidrug resistance protein 4 (MRP4) is a broadly expressed ATP-binding cassette transporter that is unique among the MRP subfamily for transporting prostanoids, a group of signaling molecules derived from unsaturated fatty acids. To bette...