Sara R Downs,Bec Grace,Jeffrey A Pleiss
Sara R Downs
Erin C Yang,Robby Divine,Marcos C Miranda et al.
Erin C Yang et al.
Programming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and is important for targeted delivery of biologics. Here we describe the design of octahedral non-porous nanopart...
Cryo-EM structure of the Rev1-Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis [0.03%]
Rev1-Polζ全酶的冷冻电镜结构揭示了其在跨损伤DNA合成中的协同作用机制
Radhika Malik,Robert E Johnson,Iban Ubarretxena-Belandia et al.
Radhika Malik et al.
Rev1-Polζ-dependent translesion synthesis (TLS) of DNA is crucial for maintaining genome integrity. To elucidate the mechanism by which the two polymerases cooperate in TLS, we determined the cryogenic electron microscopic structure of the...
Illuminating cortactin structure and function at actin filament branches [0.03%]
亮明肌动蛋白分支上皮质类泛素结构和功能
Klemens Rottner,Peter Bieling
Klemens Rottner
Daniel J Sprague,Sang-Kyu Park,Svenja Gramberg et al.
Daniel J Sprague et al.
Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases-for example, the parasitic blood fluke infection schistosomiasis-are treated with the drug praziquantel (PZQ). However, PZQ is ...
Anne R Wondisford,Junyeop Lee,Robert Lu et al.
Anne R Wondisford et al.
The recognition that DNA can be ADP ribosylated provides an unexpected regulatory level of how ADP-ribosylation contributes to genome stability, epigenetics and immunity. Yet, it remains unknown whether DNA ADP-ribosylation (DNA-ADPr) promo...
Ylli Doksani,Francisca Lottersberger
Ylli Doksani
Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT3 receptors [0.03%]
抗抑郁药沃西汀在人和rodent5-HT3受体上的活性结构决定因素
Uriel López-Sánchez,Lachlan Jake Munro,Lucy Kate Ladefoged et al.
Uriel López-Sánchez et al.
Vortioxetine (VTX) is a recently approved antidepressant that targets a variety of serotonin receptors. Here, we investigate the drug's molecular mechanism of operation at the serotonin 5-HT3 receptor (5-HT3R), which features two properties...