Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT3 receptors
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Vortioxetine (VTX) is a recently approved antidepressant that targets a variety of serotonin receptors. Here, we investigate the drug's molecular mechanism of operation at the serotonin 5-HT3 receptor (5-HT3R), which features two properties: VTX acts different... ...
