Hemant K Prajapati,Peter R Eriksson,Paul A Elizalde et al.
Hemant K Prajapati et al.
Eukaryotic genomes are packaged into chromatin, which is composed of condensed filaments of regularly spaced nucleosomes, resembling beads on a string. The nucleosome contains ~147 bp of DNA wrapped almost twice around a central core histon...
Structural insights into SV2A and the mechanism of racetam anticonvulsants [0.03%]
SV2A的结构及 Racetam类抗惊厥机理的洞察
Mazdak M Bradberry,Edwin R Chapman
Mazdak M Bradberry
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure [0.03%]
钠离子伏打ATP酶抑制剂可遏制耐万古霉素肠球菌生长并揭示其钠离子通道结构
Kano Suzuki,Yoshiyuki Goto,Akihiro Otomo et al.
Kano Suzuki et al.
Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections, particularly endocarditis and sepsis. With the diminishing effectiveness of antibiotics against VRE, new antimicrobial agents are urgently needed. Ou...
Architecture and activation of single-pass transmembrane receptor guanylyl cyclase [0.03%]
单通道跨膜受体鸟苷酸环化酶的结构和激活机制
Shian Liu,Alexander M Payne,Jinan Wang et al.
Shian Liu et al.
The heart, in addition to its primary role in blood circulation, functions as an endocrine organ by producing cardiac hormone natriuretic peptides. These hormones regulate blood pressure through the single-pass transmembrane receptor guanyl...
Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair [0.03%]
Vipp1螺旋形成、环体生成及膜修复的机制
Souvik Naskar,Andrea Merino,Javier Espadas et al.
Souvik Naskar et al.
The ESCRT-III-like protein Vipp1 couples filament polymerization with membrane remodeling. It assembles planar sheets as well as 3D rings and helical polymers, all implicated in mitigating plastid-associated membrane stress. The architectur...
Jan-Hannes Schäfer,Lena Clausmeyer,Carolin Körner et al.
Jan-Hannes Schäfer et al.
Ceramides are essential lipids involved in forming complex sphingolipids and acting as signaling molecules. They result from the N-acylation of a sphingoid base and a CoA-activated fatty acid, a reaction catalyzed by the ceramide synthase (...
Structural basis of the mechanism and inhibition of a human ceramide synthase [0.03%]
人型神经酰胺合酶的结构基础及其抑制机制研究
Tomas C Pascoa,Ashley C W Pike,Christofer S Tautermann et al.
Tomas C Pascoa et al.
Ceramides are bioactive sphingolipids crucial for regulating cellular metabolism. Ceramides and dihydroceramides are synthesized by six ceramide synthase (CerS) enzymes, each with specificity for different acyl-CoA substrates. Ceramide with...
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes [0.03%]
cryo-电子断层扫描揭示COPII如何在含货物膜上组装
Euan Pyle,Elizabeth A Miller,Giulia Zanetti
Euan Pyle
Proteins traverse the eukaryotic secretory pathway through membrane trafficking between organelles. The coat protein complex II (COPII) mediates the anterograde transport of newly synthesized proteins from the endoplasmic reticulum, engagin...
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets [0.03%]
丝束蛋白乙酰转移酶通过紫杉醇结合口袋中的锚定位点接近并修饰微管蛋白腔内赖氨酸40残基
Jingyi Luo,Wai Hei Lam,Daqi Yu et al.
Jingyi Luo et al.
Acetylation at α-tubulin K40 is the sole post-translational modification preferred to occur inside the lumen of hollow cylindrical microtubules. However, how tubulin acetyltransferases access the luminal K40 in micrometer-long microtubules...