Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates [0.03%]
动态的PRC1-CBX8稳定了染色质凝聚物的多孔结构
Michael Uckelmann,Vita Levina,Cyntia Taveneau et al.
Michael Uckelmann et al.
The compaction of chromatin is a prevalent paradigm in gene repression. Chromatin compaction is commonly thought to repress transcription by restricting chromatin accessibility. However, the spatial organization and dynamics of chromatin co...
Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3 [0.03%]
神经甾体和抗惊厥作用调节TRPM3的分子基础
Ying Yin,Cheon-Gyu Park,Shasha Feng et al.
Ying Yin et al.
Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca2+-permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a nociceptor in the peripheral sensory system. Recent discov...
Single-molecule analysis of transcription activation: dynamics of SAGA coactivator recruitment [0.03%]
单分子水平上的转录激活分析：SAGA共激活子募集的动态过程研究
Jongcheol Jeon,Larry J Friedman,Daniel H Zhou et al.
Jongcheol Jeon et al.
Transcription activators are said to stimulate gene expression by 'recruiting' coactivators, yet this vague term fits multiple kinetic models. To directly analyze the dynamics of activator-coactivator interactions, single-molecule microscop...
Binding mechanism and antagonism of the vesicular acetylcholine transporter VAChT [0.03%]
囊泡乙酰胆碱转运蛋白(VAChT)的结合机制及其颉颃作用
Qiao Ma,Kunpeng Ma,Yanli Dong et al.
Qiao Ma et al.
The vesicular acetylcholine transporter (VAChT) has a pivotal role in packaging and transporting acetylcholine for exocytotic release, serving as a vital component of cholinergic neurotransmission. Dysregulation of its function can result i...
Ribosomal A-site interactions with near-cognate tRNAs drive stop codon readthrough [0.03%]
核糖体A位点与半胱氨酸tRNA相互作用可驱动终止密码子读穿
Zuzana Čapková Pavlíková,Petra Miletínová,Adriana Roithová et al.
Zuzana Čapková Pavlíková et al.
Transfer RNAs (tRNAs) serve as a dictionary for the ribosome translating the genetic message from mRNA into a polypeptide chain. In addition to this canonical role, tRNAs are involved in other processes such as programmed stop codon readthr...
Structure and catalytic mechanism of exogenous fatty acid recycling by AasS, a versatile acyl-ACP synthetase [0.03%]
多功能酰基-ACP合成酶AasS催化的外源脂肪酸再利用机制及结构研究
Haomin Huang,Chen Wang,Shenghai Chang et al.
Haomin Huang et al.
Fatty acids (FAs) are essential building blocks for all the domains of life, of which bacterial de novo synthesis, called type II FA synthesis (FAS II), is energetically expensive. The recycling of exogenous FAs (eFAs) partially relieves th...
Dustin C Becht,Karthik Selvam,Catherine Lachance et al.
Dustin C Becht et al.
The epigenetic cofactor ENL (eleven-nineteen-leukemia) and the acetyltransferase MOZ (monocytic leukemia zinc finger) have vital roles in transcriptional regulation and are implicated in aggressive forms of leukemia. Here, we describe the m...
Philipp Münick,Alexander Strubel,Dimitrios-Ilias Balourdas et al.
Philipp Münick et al.
Infection of cells with high-risk strains of the human papillomavirus (HPV) causes cancer in various types of epithelial tissue. HPV infections are responsible for ~4.5% of all cancers worldwide. Tumorigenesis is based on the inactivation o...
RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation [0.03%]
RapA通过打开RNA聚合酶夹板来破坏终止后复合物并防止细胞毒性R环形成
Joshua J Brewer,Koe Inlow,Rachel A Mooney et al.
Joshua J Brewer et al.
Following transcript release during intrinsic termination, Escherichia coli RNA polymerase (RNAP) often remains associated with DNA in a post-termination complex (PTC). RNAPs in PTCs are removed from the DNA by the SWI2/SNF2 adenosine triph...
Inherent asymmetry of Rpd3S coordinates its nucleosome engagement and association with elongating RNA polymerase II [0.03%]
Rpd3S固有的不对称性协调其与核小体的相互作用及其与延长型RNA聚合酶II的关联
Yixuan Pan,Meiyang Liu,Chun Ruan et al.
Yixuan Pan et al.
The Rpd3S histone deacetylase complex has a crucial role in genomic integrity by deacetylating transcribed nucleosomes following RNA polymerase (Pol) II passage. Cryo-EM studies highlight the importance of asymmetrical Rco1-Eaf3 dimers in n...