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Inherent asymmetry of Rpd3S coordinates its nucleosome engagement and association with elongating RNA polymerase II

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The Rpd3S histone deacetylase complex has a crucial role in genomic integrity by deacetylating transcribed nucleosomes following RNA polymerase (Pol) II passage. Cryo-EM studies highlight the importance of asymmetrical Rco1-Eaf3 dimers in nucleosome binding, y... ...