Author Correction: DELE1 oligomerization promotes integrated stress response activation [0.03%]
作者更正：DELE1低聚物化促进综合压力反应激活
Jie Yang,Kelsey R Baron,Daniel E Pride et al.
Jie Yang et al.
Published Erratum
Nature structural & molecular biology. 2025 Apr 2. DOI:10.1038/s41594-025-01547-z 2025
Structural basis for membrane remodeling by the AP5-SPG11-SPG15 complex [0.03%]
AP5-SPG11-SPG15复合体重塑质膜的结构基础
Xinyi Mai,Yang Wang,Xi Wang et al.
Xinyi Mai et al.
The human spastizin (spastic paraplegia 15, SPG15) and spatacsin (spastic paraplegia 11, SPG11) complex is involved in the formation of lysosomes, and mutations in these two proteins are linked with hereditary autosomal-recessive spastic pa...
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide [0.03%]
OGT通过限制基因组范围内的TET活性来防止DNA去甲基化并抑制异染色质中转座元件的表达
Hugo Sepulveda,Xiang Li,Leo J Arteaga-Vazquez et al.
Hugo Sepulveda et al.
O-GlcNAc transferase (OGT) interacts robustly with all three mammalian TET methylcytosine dioxygenases. Here we show that deletion of the Ogt gene in mouse embryonic stem (mES) cells results in a widespread increase in the TET product 5-hyd...
John McCullough,Wesley I Sundquist
John McCullough
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling [0.03%]
抑制去泛素酶活性和炎症信号的分子粘合剂
Francesca Chandler,Poli Adi Narayana Reddy,Smita Bhutda et al.
Francesca Chandler et al.
Deubiquitylases (DUBs) are crucial in cell signaling and are often regulated by interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signaling by cleaving K63-linked polyubiquitin chains on t...
A nuclear pore-anchored condensate enables germ granule organization and transgenerational epigenetic inheritance [0.03%]
核孔锚定的凝聚物使生殖颗粒组织和跨代表观遗传继承成为可能
Pu Lu,Boyuan Deng,Xinru Li et al.
Pu Lu et al.
Biomolecular condensates, such as stress and germ granules, often contain subcompartments. For instance, the Caenorhabditis elegans germ granule, which localizes near the outer nuclear membrane of germ cell nuclei, is composed of at least f...