Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37 [0.03%]
E3连接酶TRIM37对微管组织中心的介尺度调节作用
Zhong Y Yeow,Sonia Sarju,Fang-Chi Chang et al.
Zhong Y Yeow et al.
Centrosomes ensure accurate chromosome segregation during cell division. Although the regulation of centrosome number is well established, less is known about the suppression of noncentrosomal microtubule-organizing centers (ncMTOCs). The E...
Renata Basto
Renata Basto
Multiple steps of dynein activation by Lis1 visualized by cryo-EM [0.03%]
通过冷冻电子显微镜观察到的Lis1分步激活动力蛋白的过程
Agnieszka A Kendrick,Kendrick H V Nguyen,Wen Ma et al.
Agnieszka A Kendrick et al.
Cytoplasmic dynein-1 (dynein) is an essential molecular motor controlled in part by autoinhibition. Lis1, a key dynein regulator mutated in the neurodevelopmental disease lissencephaly, plays a role in dynein activation. We recently identif...
Making 3' ends meet [0.03%]
让3'端共存
Sylvie Doublié
Sylvie Doublié
Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual [0.03%]
全长度Pfs48/45与自然暴露个体中分离得到的高效单克隆抗体复合物的结构解析
Iga Kucharska,Danton Ivanochko,Sophia Hailemariam et al.
Iga Kucharska et al.
Biomedical interventions that block the transmission of Plasmodium falciparum (Pf) from humans to mosquitoes may be critical for malaria elimination. Pfs48/45, a gamete-surface protein essential for Pf development in the mosquito midgut, is...
Alejandra Laguillo-Diego,Effie Apostolou
Alejandra Laguillo-Diego
Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex [0.03%]
吉氏吸虫呼吸链超级复合物的结构、装配及其抑制作用
Andrew E MacLean,Shikha Shikha,Mariana Ferreira Silva et al.
Andrew E MacLean et al.
The apicomplexan mitochondrial electron transport chain is essential for parasite survival and displays a divergent subunit composition. Here we report cryo-electron microscopy structures of an apicomplexan III2-IV supercomplex and of the d...
The importance of physiological and disease contexts in capturing mRNA modifications [0.03%]
生理和疾病背景在捕获mRNA修饰中的重要性
Audrey Penning,François Fuks
Audrey Penning
The variety of modifications decorating various RNA species has prompted researchers to study messenger RNA (mRNA) modifications that are likely to have, like N6-methyladenosine (m6A), important biological functions. Yet tackling these modi...
Melina Casadio
Melina Casadio