Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state [0.03%]
不含核苷酸的Chd1染色质重塑复合物的单分子光镊研究及其对核小体的作用机制
Ilana M Nodelman,Sayan Das,Anneliese M Faustino et al.
Ilana M Nodelman et al.
Chromatin remodelers are ATP-dependent enzymes that reorganize nucleosomes within all eukaryotic genomes. Here we report a complex of the Chd1 remodeler bound to a nucleosome in a nucleotide-free state, determined by cryo-EM to 2.3 Å resol...
Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2 [0.03%]
哺乳动物Na+/H+交换器NHA2的结构、机制及脂质介导的重塑作用
Rei Matsuoka,Roman Fudim,Sukkyeong Jung et al.
Rei Matsuoka et al.
The Na+/H+ exchanger SLC9B2, also known as NHA2, correlates with the long-sought-after Na+/Li+ exchanger linked to the pathogenesis of diabetes mellitus and essential hypertension in humans. Despite the functional importance of NHA2, struct...
Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery [0.03%]
泛素连接酶Panoramix介导的染色质SUMO化连接piRNA途径和异染色质机器
Veselin I Andreev,Changwei Yu,Juncheng Wang et al.
Veselin I Andreev et al.
Nuclear Argonaute proteins, guided by small RNAs, mediate sequence-specific heterochromatin formation. The molecular principles that link Argonaute-small RNA complexes to cellular heterochromatin effectors on binding to nascent target RNAs ...
Yao Shen,Josue Gomez-Blanco,Michael T Petassi et al.
Yao Shen et al.
Tn7 transposable elements are unique for their highly specific, and sometimes programmable, target-site selection mechanisms and precise insertions. All the elements in the Tn7 family utilize an AAA+ adaptor (TnsC) to coordinate target-site...
Author Correction: Retinoic acid signaling is critical during the totipotency window in early mammalian development [0.03%]
作者更正：视黄酸信号在哺乳动物早期发育全能性窗口期至关重要
Ane Iturbide,Mayra L Ruiz Tejada Segura,Camille Noll et al.
Ane Iturbide et al.
Published Erratum
Nature structural & molecular biology. 2022 Mar;29(3):282. DOI:10.1038/s41594-022-00740-8 2022
Hongwei Zhang,Jiawei Su,Bin Li et al.
Hongwei Zhang et al.
Glycosylphosphatidylinositol (GPI) molecules are complex glycophospholipids and serve as membrane anchors for tethering many proteins to the cell surface. Attaching GPI to the protein in the endoplasmic reticulum (ER) is catalyzed by the tr...
Caillan Crowe-McAuliffe,Daniel N Wilson
Caillan Crowe-McAuliffe
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics [0.03%]
噁唑烷酮抗生素特异性抑制翻译的分子机制
Kaitlyn Tsai,Vanja Stojković,D John Lee et al.
Kaitlyn Tsai et al.
The antibiotic linezolid, the first clinically approved member of the oxazolidinone class, inhibits translation of bacterial ribosomes by binding to the peptidyl transferase center. Recent work has demonstrated that linezolid does not inhib...
Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol [0.03%]
氯霉素作为经典肽基转移酶抑制剂的作用机制及其结构基础
Egor A Syroegin,Laurin Flemmich,Dorota Klepacki et al.
Egor A Syroegin et al.
Ribosome-targeting antibiotics serve as powerful antimicrobials and as tools for studying the ribosome, the catalytic peptidyl transferase center (PTC) of which is targeted by many drugs. The classic PTC-acting antibiotic chloramphenicol (C...
Beth Moorefield
Beth Moorefield