Author Correction: SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity [0.03%]
作者更正：类似SETDB1的MET-2在缺乏其H3K9三甲基化相关催化活性的情况下可独立促进转录沉默和发育
Colin E Delaney,Stephen P Methot,Veronique Kalck et al.
Colin E Delaney et al.
Published Erratum
Nature structural & molecular biology. 2022 May;29(5):502. DOI:10.1038/s41594-022-00776-w 2022
Keda Zhou,Magdalena Gebala,Dustin Woods et al.
Keda Zhou et al.
The histone variant CENP-A is the epigenetic determinant for the centromere, where it is interspersed with canonical H3 to form a specialized chromatin structure that nucleates the kinetochore. How nucleosomes at the centromere arrange into...
Katrina V Good,Juan Ausió
Katrina V Good
A tweak and a peek: How Cas9 pries open double-stranded DNA to check its sequence [0.03%]
一探与二看：Cas9 如何撬开双链DNA以检查其序列
Selma Sinan,Rick Russell
Selma Sinan
Joshua C Cofsky,Katarzyna M Soczek,Gavin J Knott et al.
Joshua C Cofsky et al.
In bacterial defense and genome editing applications, the CRISPR-associated protein Cas9 searches millions of DNA base pairs to locate a 20-nucleotide, guide RNA-complementary target sequence that abuts a protospacer-adjacent motif (PAM). T...
David Jeruzalmi
David Jeruzalmi
Beth Moorefield
Beth Moorefield
Jie Li,Junhee Park,John P Mayer et al.
Jie Li et al.
Insulin receptor (IR) signaling controls multiple facets of animal physiology. Maximally four insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise functional roles of each binding event during IR activat...
Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization [0.03%]
AP2适配体-clathrin核小体结构调控内吞的分子机制研究
Edward A Partlow,Kevin S Cannon,Gunther Hollopeter et al.
Edward A Partlow et al.
Clathrin-mediated endocytosis (CME) is the main route of internalization from the plasma membrane. It is known that the heterotetrameric AP2 clathrin adaptor must open to simultaneously engage membrane and endocytic cargo, yet it is unclear...
Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging [0.03%]
HIV-1 5'-UTR的长程和短程相互作用调控基因组二聚化与包装
Liqing Ye,Anne-Sophie Gribling-Burrer,Patrick Bohn et al.
Liqing Ye et al.
RNA dimerization is the noncovalent association of two human immunodeficiency virus-1 (HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a prerequisite for binding to the viral structural protein Pr55Gag durin...