Ashley M Toye
Ashley M Toye
Inactive and active state structures template selective tools for the human 5-HT5A receptor [0.03%]
人类5-羟色胺5A受体的非活性和活性构象模板选择工具
Shicheng Zhang,He Chen,Chengwei Zhang et al.
Shicheng Zhang et al.
Serotonin receptors are important targets for established therapeutics and drug development as they are expressed throughout the human body and play key roles in cell signaling. There are 12 serotonergic G protein-coupled receptor members e...
Kinetic principles underlying pioneer function of GAGA transcription factor in live cells [0.03%]
GAGA转录因子在活细胞中作为拓殖因子的动力学原理
Xiaona Tang,Taibo Li,Sheng Liu et al.
Xiaona Tang et al.
How pioneer factors interface with chromatin to promote accessibility for transcription control is poorly understood in vivo. Here, we directly visualize chromatin association by the prototypical GAGA pioneer factor (GAF) in live Drosophila...
Francesca Vallese,Kookjoo Kim,Laura Y Yen et al.
Francesca Vallese et al.
The stability and shape of the erythrocyte membrane is provided by the ankyrin-1 complex, but how it tethers the spectrin-actin cytoskeleton to the lipid bilayer and the nature of its association with the band 3 anion exchanger and the Rhes...
Eugene Kim,Alejandro Martin Gonzalez,Biswajit Pradhan et al.
Eugene Kim et al.
Condensin, a structural maintenance of chromosomes (SMC) complex, has been shown to be a molecular motor protein that organizes chromosomes by extruding loops of DNA. In cells, such loop extrusion is challenged by many potential conflicts, ...
Parkinson's disease risk protein TMEM175 keeps lysosomes running on a proton leak [0.03%]
帕金森病风险蛋白TMEM175通过质子泄漏维持溶酶体功能
Carolina N Perdigoto
Carolina N Perdigoto
Yang Yue,Lier Liu,Li-Jie Wu et al.
Yang Yue et al.
The technique of cryogenic-electron microscopy (cryo-EM) has revolutionized the field of membrane protein structure and function with a focus on the dominantly observed molecular species. This report describes the structural characterizatio...
Author Correction: Plasticity in ligand recognition at somatostatin receptors [0.03%]
作者更正： somatostatin 受体的配体识别的可塑性
Michael J Robertson,Justin G Meyerowitz,Ouliana Panova et al.
Michael J Robertson et al.
Published Erratum
Nature structural & molecular biology. 2022 Aug;29(8):841. DOI:10.1038/s41594-022-00813-8 2022
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans [0.03%]
白色念珠菌几丁质合成酶的抑制和调节作用的结构基础
Zhenning Ren,Abhishek Chhetri,Ziqiang Guan et al.
Zhenning Ren et al.
Chitin is an essential component of the fungal cell wall. Chitin synthases (Chss) catalyze chitin formation and translocation across the membrane and are targets of antifungal agents, including nikkomycin Z and polyoxin D. Lack of structura...
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening [0.03%]
端粒缺失缩短情况下，端粒8-氧鸟嘌呤驱动细胞快速衰老
Ryan P Barnes,Mariarosaria de Rosa,Sanjana A Thosar et al.
Ryan P Barnes et al.
Oxidative stress is a primary cause of cellular senescence and contributes to the etiology of numerous human diseases. Oxidative damage to telomeric DNA has been proposed to cause premature senescence by accelerating telomere shortening. He...