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期刊名:Nature structural & molecular biology

缩写:NAT STRUCT MOL BIOL

ISSN:1545-9993

e-ISSN:1545-9985

IF/分区:10.1/Q1

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共收录本刊相关文章索引3771
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Clemens Grimm,Julia Bartuli,Bettina Boettcher et al. Clemens Grimm et al.
Poxviruses express their genes in the cytoplasm of infected cells using a virus-encoded multi-subunit polymerase (vRNAP) and unique transcription factors. We present cryo-EM structures that uncover the complete transcription initiation phas...
K Stakyte,M Rotheneder,K Lammens et al. K Stakyte et al.
Human checkpoint kinase ataxia telangiectasia-mutated (ATM) plays a key role in initiation of the DNA damage response following DNA double-strand breaks. ATM inhibition is a promising approach in cancer therapy, but, so far, detailed insigh...
Qinhui Rao,Long Han,Yue Wang et al. Qinhui Rao et al.
Thousands of outer-arm dyneins (OADs) are arrayed in the axoneme to drive a rhythmic ciliary beat. Coordination among multiple OADs is essential for generating mechanical forces to bend microtubule doublets (MTDs). Using electron microscopy...
Qin Cao,David R Boyer,Michael R Sawaya et al. Qin Cao et al.
Amyloidosis of human islet amyloid polypeptide (hIAPP) is a pathological hallmark of type II diabetes (T2D), an epidemic afflicting nearly 10% of the world's population. To visualize disease-relevant hIAPP fibrils, we extracted amyloid fibr...
Nicholas B Woodall,Zara Weinberg,Jesslyn Park et al. Nicholas B Woodall et al.
Kinases play central roles in signaling cascades, relaying information from the outside to the inside of mammalian cells. De novo designed protein switches capable of interfacing with tyrosine kinase signaling pathways would open new avenue...