Structure of the human cone photoreceptor cyclic nucleotide-gated channel [0.03%]
人眼锥体感光细胞环核苷酸门控离子通道的结构
Xiangdong Zheng,Zhengshan Hu,Huan Li et al.
Xiangdong Zheng et al.
Cyclic nucleotide-gated (CNG) channels transduce light-induced chemical signals into electrical signals in retinal cone and rod photoreceptors. Structures of native CNG channels, which are heterotetramers formed by CNGA and CNGB subunits, h...
The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods [0.03%]
牛视网膜杆细胞原生CNGA1/CNGB1 CNG通道的结构
Diane C A Barret,Gebhard F X Schertler,U Benjamin Kaupp et al.
Diane C A Barret et al.
In rod photoreceptors of the retina, the cyclic nucleotide-gated (CNG) channel is composed of three CNGA and one CNGB subunits, and it closes in response to light activation to generate an electrical signal that is conveyed to the brain. He...
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase [0.03%]
DNA装载的MCM双六聚体选择性地被Dbf4依赖性激酶磷酸化的结构机制
Julia F Greiwe,Thomas C R Miller,Julia Locke et al.
Julia F Greiwe et al.
Loading of the eukaryotic replicative helicase onto replication origins involves two MCM hexamers forming a double hexamer (DH) around duplex DNA. During S phase, helicase activation requires MCM phosphorylation by Dbf4-dependent kinase (DD...
ESKAPE velocity: total synthesis platforms promise to increase the pace and diversity of antibiotic development [0.03%]
ESKAPE速度：-total合成平台有望加快和增加抗生素开发的速度和多样性
Jacob M Mattingly,Christine M Dunham
Jacob M Mattingly
Decoupling of degradation from deadenylation reshapes poly(A) tail length in yeast meiosis [0.03%]
酵母减数分裂中降解与去腺苷化的解耦重塑多（A）尾长度
David Wiener,Yaron Antebi,Schraga Schwartz
David Wiener
Nascent messenger RNA is endowed with a poly(A) tail that is subject to gradual deadenylation and subsequent degradation in the cytoplasm. Deadenylation and degradation rates are typically correlated, rendering it difficult to dissect the d...
Fungicidal amphotericin B sponges are assemblies of staggered asymmetric homodimers encasing large void volumes [0.03%]
fungicidal两性霉素B海绵是阶梯式不对称同二聚体的集合，包含大量空腔体积
Agnieszka Lewandowska,Corinne P Soutar,Alexander I Greenwood et al.
Agnieszka Lewandowska et al.
Amphotericin B (AmB) is a powerful but toxic fungicide that operates via enigmatic small molecule-small molecule interactions. This mechanism has challenged the frontiers of structural biology for half a century. We recently showed AmB prim...
Agata D Misiaszek,Mathias Girbig,Helga Grötsch et al.
Agata D Misiaszek et al.
RNA polymerase I (Pol I) specifically synthesizes ribosomal RNA. Pol I upregulation is linked to cancer, while mutations in the Pol I machinery lead to developmental disorders. Here we report the cryo-EM structure of elongating human Pol I ...
Carolina N Perdigoto
Carolina N Perdigoto
Florian Ullrich
Florian Ullrich
Sara Osman
Sara Osman