Geoffrey Fudenberg,Elphège P Nora
Geoffrey Fudenberg
Alexander B Tong,Jason D Burch,Daniel McKay et al.
Alexander B Tong et al.
Clemens Grimm,Julia Bartuli,Bettina Boettcher et al.
Clemens Grimm et al.
Poxviruses express their genes in the cytoplasm of infected cells using a virus-encoded multi-subunit polymerase (vRNAP) and unique transcription factors. We present cryo-EM structures that uncover the complete transcription initiation phas...
K Stakyte,M Rotheneder,K Lammens et al.
K Stakyte et al.
Human checkpoint kinase ataxia telangiectasia-mutated (ATM) plays a key role in initiation of the DNA damage response following DNA double-strand breaks. ATM inhibition is a promising approach in cancer therapy, but, so far, detailed insigh...
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism [0.03%]
微管双联体上外臂二联球蛋白排列的结构揭示了分子马达协调机制
Qinhui Rao,Long Han,Yue Wang et al.
Qinhui Rao et al.
Thousands of outer-arm dyneins (OADs) are arrayed in the axoneme to drive a rhythmic ciliary beat. Coordination among multiple OADs is essential for generating mechanical forces to bend microtubule doublets (MTDs). Using electron microscopy...
Carolina N Perdigoto
Carolina N Perdigoto
PIEZOs in vacuoles [0.03%]
溶酶体中的PIEZO蛋白
Florian Ullrich
Florian Ullrich
Adding complexity to NHEJ [0.03%]
NHEJ复杂性的增加
Beth Moorefield
Beth Moorefield
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores [0.03%]
由患者提取的纤维素种子引发的hIAPP纤维的低温电镜结构揭示了新的多晶型物和保守的纤维核心
Qin Cao,David R Boyer,Michael R Sawaya et al.
Qin Cao et al.
Amyloidosis of human islet amyloid polypeptide (hIAPP) is a pathological hallmark of type II diabetes (T2D), an epidemic afflicting nearly 10% of the world's population. To visualize disease-relevant hIAPP fibrils, we extracted amyloid fibr...
Nicholas B Woodall,Zara Weinberg,Jesslyn Park et al.
Nicholas B Woodall et al.
Kinases play central roles in signaling cascades, relaying information from the outside to the inside of mammalian cells. De novo designed protein switches capable of interfacing with tyrosine kinase signaling pathways would open new avenue...