Mammalian PERIOD2 regulates H2A.Z incorporation in chromatin to orchestrate circadian negative feedback [0.03%]
哺乳动物PERIOD2通过调节组蛋白H2A.Z在染色质中的镶嵌来调控昼夜节律负反馈循环
Kevin Tartour,Francesca Andriani,Eric G Folco et al.
Kevin Tartour et al.
Mammalian circadian oscillators are built on a feedback loop in which the activity of the transcription factor CLOCK-BMAL1 is repressed by the PER-CRY complex. Here, we show that murine Per-/- fibroblasts display aberrant nucleosome occupan...
Allosteric regulation controls actin-bundling properties of human plastins [0.03%]
别构调节控制人类plastin的肌动蛋白聚集性质
Christopher L Schwebach,Elena Kudryashova,Richa Agrawal et al.
Christopher L Schwebach et al.
Plastins/fimbrins are conserved actin-bundling proteins contributing to motility, cytokinesis and other cellular processes by organizing strikingly different actin assemblies as in aligned bundles and branched networks. We propose that this...
Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory [0.03%]
组蛋白H1与核小体阵列的结合依赖于链接DNA的长度和轨迹
Marco Dombrowski,Maik Engeholm,Christian Dienemann et al.
Marco Dombrowski et al.
Throughout the genome, nucleosomes often form regular arrays that differ in nucleosome repeat length (NRL), occupancy of linker histone H1 and transcriptional activity. Here, we report cryo-EM structures of human H1-containing tetranucleoso...
Building a molecular rotor [0.03%]
构建分子转子
Florian Ullrich
Florian Ullrich
Carolina N Perdigoto
Carolina N Perdigoto
Beth Moorefield
Beth Moorefield
Elena A Zehr,Antonina Roll-Mecak
Elena A Zehr
Cryo-EM structure of the human CST-Polα/primase complex in a recruitment state [0.03%]
人类CST-Polα/原核复合物募集状态下的低温EM结构
Sarah W Cai,John C Zinder,Vladimir Svetlov et al.
Sarah W Cai et al.
The CST-Polα/primase complex is essential for telomere maintenance and functions to counteract resection at double-strand breaks. We report a 4.6-Å resolution cryo-EM structure of human CST-Polα/primase, captured prior to catalysis in a ...
Ciliary central apparatus structure reveals mechanisms of microtubule patterning [0.03%]
纤毛中央发生装置结构揭示了微管图案形成的机制
Miao Gui,Xiangli Wang,Susan K Dutcher et al.
Miao Gui et al.
A pair of extensively modified microtubules form the central apparatus (CA) of the axoneme of most motile cilia, where they regulate ciliary motility. The external surfaces of both CA microtubules are patterned asymmetrically with large pro...
Long Han,Qinhui Rao,Renbin Yang et al.
Long Han et al.
Accurately regulated ciliary beating in time and space is critical for diverse cellular activities, which impact the survival and development of nearly all eukaryotic species. An essential beating regulator is the conserved central apparatu...