Antimelanoma Activity of the Mastoparan Peptides MPX and MP1: Cellular Selectivity and Mechanism of Action [0.03%]
mastoparan 类衍生物MPX和MP1的抗黑色素瘤活性及其作用机制和选择性
Amanda Sansone Semerdjian,Manoel Arcisio-Miranda
Amanda Sansone Semerdjian
MPX (Mastoparan X) and MP1 (Polybia-MP1) are cationic amphiphilic peptides isolated from the venom of insects of the Vespidae family. Due to their physicochemical features, these peptides show affinity for biomimetic membranes, especially t...
Silver Nanoparticle Coated with Deep Eutectic Solvent as an Effective Medium for Improving the Structural and Thermal Stability of Immunoglobulin G Antibodies [0.03%]
包覆深共熔溶剂的银纳米粒子可改善免疫球蛋白G抗体稳定性的有效介质研究
Urooj Fatima,Pooja Yadav,Diksha Dhiman et al.
Urooj Fatima et al.
Immunoglobulin G (IgG), widely used in therapeutic and diagnostic applications, is prone to denaturation and aggregation, reducing bioactivity and shelf life and increasing immunogenic risks. Current methods fall short of preserving IgG's s...
Dihydroartemisinin-Loaded ZIF-8 Nanoparticles Elicit Chemo-Immunotherapy against Malignant Pleural Effusion via Inhibition of OCT4/M-CSF Signaling Pathway [0.03%]
二氢青蒿素载药ZIF-8纳米颗粒通过抑制OCT4/M-CSF信号通路释放恶性胸水的化疗免疫疗法
Hui You,Liu-Gen Li,Chuan-Yong Xiao et al.
Hui You et al.
Malignant pleural effusion (MPE) is the most common complication of lung cancer with an extremely high lethality, for which no effective chemotherapeutic agent is available. Activation of local antitumor immunity of MPE while selectively de...
CD64-Targeted Polymer-Drug Conjugates Exploit Cathepsin K-Dependent Payload Release for Selective Elimination of Immunosuppressive Macrophages [0.03%]
靶向CD64的聚合物-药物偶联物通过依赖组织蛋白酶K释放有效载荷来选择性消除免疫抑制型巨噬细胞
Dominik Musil,Markéta Krhutová,Kristýna Blažková et al.
Dominik Musil et al.
Selective depletion of immunosuppressive macrophages in the tumor microenvironment is a promising strategy in cancer therapy. CD64 is broadly expressed on myeloid cells, including both pro-inflammatory M1-like and immunosuppressive M2-like ...
Near-UV and Visible Light Promote Iron-Catalyzed Site-Specific Radical Transformation of Threonine to Alanine in a Monoclonal Antibody Fc Domain (IgG1-Fc) [0.03%]
近紫外光和可见光促进铁催化免疫球蛋白G1-Fc区域中苏氨酸到丙氨酸的位点特异性自由基转化
Maribel Espinoza Ballesteros,Marcela Solis Rodriguez,Thomas J Tolbert et al.
Maribel Espinoza Ballesteros et al.
Near-UV and visible-light photodegradation is a concern for the development of stable and efficacious protein therapeutics, but mechanistic information on the underlying processes is scarce. We previously reported on the photoconversion and...
Combination Gene Therapy with AAV-Based Vectors Ameliorates the Phenotype of Type 2 Diabetes in Diet-Induced Obese and db/db Mice [0.03%]
基于AAV载体的联合基因治疗可改善高脂饮食诱导的肥胖型2型糖尿病小鼠和db/db小鼠的糖尿病症状
Ramkumar Rajendiran,Subhajit Pathak,Ashish Kumar et al.
Ramkumar Rajendiran et al.
Type 2 diabetes mellitus (T2DM) has significant treatment challenges due to its complex pathophysiology and associated comorbidities. In recent years, hepatokine fibroblast growth factor 21 (FGF21) has gained significant attention for treat...
Sorafenib-Loaded Mesoporous Fe-Hematoporphyrin Complex for Ferroptosis-Enhanced Photodynamic Therapy of Colorectal Tumor [0.03%]
负载索拉非尼的介孔Fe-血卟啉复合物用于增强铁死亡诱导的光动力 colorectal tumor 治疗
Chi Zhang,Yang Bai,Yingyi Zhang et al.
Chi Zhang et al.
Current colorectal cancer (CRC) therapies (e.g., surgery and radiotherapy) face challenges of invasiveness, drug resistance, and limited efficacy. Photodynamic therapy (PDT), a noninvasive modality, generates cytotoxic reactive oxygen speci...
Jonas Habicht,Gabriele Sadowski,Christoph Brandenbusch
Jonas Habicht
Predicting the solubility of active pharmaceutical ingredients (APIs) is essential throughout drug development. However, state-of-the-art modeling approaches require system-specific data sets for parameter estimation and are resource intens...
Smart Magnetic Nanozyme for Multimodal Dynamic Regulation to Reverse Multidrug Resistance in Breast Cancer [0.03%]
用于逆转乳腺癌多重耐药的智能磁性纳米酶多模态动态调节
Jinzhao He,Senyi Gong,Yu Liu et al.
Jinzhao He et al.
Intratumoral redox homeostasis is often implicated in the development of multidrug resistance (MDR), which compromises the oxidative cytotoxicity of anthracycline chemotherapeutics such as doxorubicin (DOX). To overcome the redox homeostasi...
Multifunctional Cannabidiol-Loaded Nanoparticles Based on Herbal-Derived Bioactive Materials Provide Enhanced Neuroprotection against Ischemic Stroke [0.03%]
基于植物来源生物活性材料的多功能载大麻二酚纳米颗粒可增强缺血性脑卒中的神经保护作用
Ming-Yan Yang,Hong-Yuan Quan,Ya-Wen Yu et al.
Ming-Yan Yang et al.
The ischemic cascade is central to the pathophysiology of ischemic stroke, making single-target strategies often inadequate. An ideal neuroprotective approach should therefore target multiple key components of the ischemic cascade. Herbal-d...