Near-UV and Visible Light Promote Iron-Catalyzed Site-Specific Radical Transformation of Threonine to Alanine in a Monoclonal Antibody Fc Domain (IgG1-Fc)
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Near-UV and visible-light photodegradation is a concern for the development of stable and efficacious protein therapeutics, but mechanistic information on the underlying processes is scarce. We previously reported on the photoconversion and photofragmentation ... ...
