Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans [0.03%]
遗传异合体-转录同合体IRF7缺陷导致人类疱疹病毒中枢神经系统感染
Marvin Werner,Jonas Holst Wolff,Justin Taft et al.
Marvin Werner et al.
Inborn errors of immunity (IEI) impairing brain-intrinsic immune defenses can underlie herpes simplex virus encephalitis. By whole-exome sequencing of cohorts of herpesvirus-associated recurrent lymphocytic meningitis and acute retinal necr...
Andrea M Cooper
Andrea M Cooper
Mycobacterium tuberculosis drives expression of type I IFN-mediated neutrophil accumulation, which limits interaction between CD4 T cells and macrophages. Failure to limit type I IFN very early in the interaction between Mtb and immune cell...
Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle [0.03%]
聚谷氨酰胺疾病的发病机制：拼凑复杂的分子谜题
Esmeralda Villavicencio Gonzalez,Huda Y Zoghbi
Esmeralda Villavicencio Gonzalez
Polyglutamine (polyQ) diseases, caused by a CAG repeat expansion encoding a glutamine tract in nine distinct proteins, present a complex molecular puzzle in which each piece contributes to neurodegeneration. While each of the causative prot...
Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells [0.03%]
胸导管髓系细胞是异质的，并包含一种新型过渡性树突状细胞群
Matouš Vobořil,Fernando Bandeira Sulczewski,Ryan J Martinez et al.
Matouš Vobořil et al.
Myeloid cells, including dendritic cells (DCs) and macrophages, are essential for establishing central tolerance in the thymus by promoting T cell clonal deletion and regulatory T cell (Treg) generation. Previous studies suggest that the th...
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance [0.03%]
成本刺激阻断下的口服抗原暴露诱导Tregs建立免疫耐受性
Masaya Arai,Ryoji Kawakami,Yamami Nakamura et al.
Masaya Arai et al.
Antigen-specific oral tolerance prevents harmful immune responses in naïve animals but is difficult to induce in antigen-primed hosts. Here, we showed that feeding of antigen-containing diet generated peripherally derived regulatory T (pTr...
Women in STEM becoming independent: Put science and discovery ahead of your ego [0.03%]
女性科学家应放下身段，专心科研
Priyadharshini Devarajan,Roberta Zappasodi,Novalia Pishesha et al.
Priyadharshini Devarajan et al.
Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis [0.03%]
杂合的人类JAK2V617F活化AhR驱动原发性血小板增多症并促进血栓形成
Li Zhou,Dongxiao Wu,Yabo Zhou et al.
Li Zhou et al.
JAK2V617F causes >50% essential thrombocythemia (ET) and >90% polycythemia vera (PV). How such a single mutation causes distinct disorders remains a long-standing enigma. Here, we show that heterozygous JAK2V617F activates the transcription...
FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes [0.03%]
Fcrl3是免疫调节性受体，可抑制人类记忆T淋巴细胞的活化
Niccolò Bianchi,Elena Foli,Mehrpouya Mostanfar et al.
Niccolò Bianchi et al.
Genetic variants in the FCRL3 gene are linked to autoimmune disorders. However, the functional properties of FCRL3-expressing T lymphocytes, and the regulation and functional impact of FCRL3 expression remain understudied. Here, we performe...
Lung tissue-resident memory T cells optimize protection by IL-10 regulation of innate immunity [0.03%]
肺组织驻留记忆T细胞通过IL-10调节固有免疫来优化保护作用
Alexander Y Yang,Julia Davis-Porada,Daniel H Paik et al.
Alexander Y Yang et al.
Respiratory viral infections establish tissue-resident memory T cells (TRM) in the lung, which provide optimal protection against subsequent infections, though the underlying mechanisms are incompletely understood. Here, we demonstrate in a...
Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1 [0.03%]
腺苷代谢清除通过精氨酸甲基化RIPK1维持肝脏稳态
Ran Liu,Gengqiao Wang,Zhengting Jiang et al.
Ran Liu et al.
Tumor necrosis factor α (TNFα) maintains homeostasis through promoting cell survival or cell death; however, how this process is regulated by metabolic pathways remains largely unknown. Here, we identify adenosine kinase (ADK), the key en...