Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity [0.03%]
靶向UBE2F诱导增强CD8+t细胞免疫力的抵抗力程序
Xiaonan Ma,Henan Guo,Yuting Jia et al.
Xiaonan Ma et al.
Memory CD8 T cells (TMEM) and exhausted CD8 T cells (TEX) are essential for host defense against infection and cancer, yet their therapeutic potential is often limited by insufficient persistence and sustained functional capacity. Strategie...
CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin [0.03%]
皮肤中的CSF1R依赖性CD169阳性巨噬细胞可局部限制黑色素瘤生长
Yuki Honda Keith,Emily Duchini,Xufeng Lin et al.
Yuki Honda Keith et al.
Macrophages in the skin reside in multiple distinct layers and perform various functions. Here, we show that CD169+ macrophages reside in the hypodermis and comprise the major skin myeloid cell population in the steady state. In a syngeneic...
Rundi Zhu,Yuqian Wang,Guideng Li
Rundi Zhu
In this issue of JEM, Liu et al. (https://doi.org/10.1084/jem.20251779) report PRECISE-seq, a proximity labeling platform that integrates T cell receptor specificity, functional potency, and cellular phenotype at a single-cell resolution. U...
Identification of secondary microglial formation centers in the human fetal brain [0.03%]
人胎儿大脑中二次微胶质形成中心的识别
Chenyun Song,Xinyu Chen,Rong Ji et al.
Chenyun Song et al.
Microglia migrate from the yolk sac and populate the developing brain. How microglia expand rapidly to meet the microglial demand in fast-expanding human fetal brains remains uncharted. Using thick sections in 5-22-gestational week (gw) bra...
Reprogramming endogenous NK circuits by highly efficient nonviral genome editing [0.03%]
高效非病毒基因组编辑重新编程内源性NK电路
Rih-Sheng Huang,Shee Kwan Phung,Darin Sumstad et al.
Rih-Sheng Huang et al.
Natural killer (NK) cells are promising platforms for off-the-shelf immunotherapy, yet nonviral precision engineering remains limited by poor HDR efficiency, DNA toxicity, and manufacturing challenges. The aim of this study was to establish...
Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2-deficient environments [0.03%]
调节性T细胞通过创建缺IL-2环境来破坏抗肿瘤γδT细胞功能
Rafael Blanco-Domínguez,André Miguel Vaz-Pinto,Leandro Barros et al.
Rafael Blanco-Domínguez et al.
Regulatory T (Treg) cells are potent immunosuppressors of conventional αβ T cells in the tumor microenvironment, but how they may affect innate-like γδ T cells remains poorly understood. Here, we show that induced Treg depletion in mice...
PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity [0.03%]
PRECISE-seq 揭示具有表型可塑性的疾病相关性 T 细胞受体库
Shibo Liu,Guanghao Liang,Yayun Yang et al.
Shibo Liu et al.
Linking T cell phenotypes with antigen specificity and functional avidity is critical for understanding in vivo immune responses in infection and cancer. Here, we develop PRECISE-seq, a method that integrates multi-omics T cell analysis wit...
Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis [0.03%]
上皮细胞趋化因子CCL25在T细胞发育和肠稳态中的整合作用
Jie Li,Mei-Ting Yang,Mami Matsuda-Lennikov et al.
Jie Li et al.
The chemokine receptor CCR9 regulates thymus colonization by T progenitors and intestinal accumulation of TCRγδ+ intraepithelial lymphocytes (IELs). CCR9-ligand chemokine CCL25 is expressed predominantly in the thymus and the small intest...
CNOT3 supports ILC2 differentiation and function by destabilizing Tbx21 and Rorc transcripts [0.03%]
CNOT3通过使Tbx21和Rorc转录本不稳定来支持ILC2分化和功能
Megumi Tatematsu,Shunsuke Takasuga,Akane Fuchimukai et al.
Megumi Tatematsu et al.
Innate lymphoid cells (ILCs) include T-bet-dependent NK and ILC1 cells, GATA-3-dependent ILC2 cells, and RORγt-dependent ILC3 cells. Their functional and developmental regulation at the posttranscriptional level remains elusive. The CCR4-N...
Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition [0.03%]
补体调节的稳态增殖控制记忆B细胞的寿命和组成分布
Evan W Cody,Mehek Ningoo,Isha Monga et al.
Evan W Cody et al.
Memory B cell (Bmem) survival is essential for guarding against reinfection, yet processes ensuring their longevity remain unclear. As decay-accelerating factor (DAF, CD55), a negative regulator of complement activation, is requisitely down...