Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes [0.03%]
GPR183感应代谢信号促进单核细胞填充肺巨噬细胞生态位
Laura Bub,Elza Evren,Stijn Verwaerde et al.
Laura Bub et al.
Monocytes populate tissues when local niches are depleted of tissue-resident macrophages, yet the tissue-derived signals controlling monocyte-to-macrophage differentiation are largely undefined. Here, we discovered that the oxysterol recept...
Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment [0.03%]
炎症通过神经源性单核细胞募集重新连接肠神经系统
Sravya Kurapati,Changsik Shin,Krisztina Szabo et al.
Sravya Kurapati et al.
Proper organization of the enteric nervous system (ENS) is critical for normal gastrointestinal (GI) physiology. Inflammatory bowel disease (IBD) disrupts key GI functions, including bowel motility. However, in many IBD patients, motility d...
Immune profiling links autoimmune hepatitis to human herpesvirus 6 and relaxin receptor antigens [0.03%]
免疫谱分析将自身免疫性肝炎与人类疱疹病毒6和松弛素受体抗原联系起来
Arielle Klepper,James Asaki,Colette M Caspar et al.
Arielle Klepper et al.
Autoimmune hepatitis (AIH) is a severe, chronic disease where IgG elevation and autoantibody profile are defining features. However, linking autoantibodies to AIH pathogenesis remains elusive. We employed phage-display immunoprecipitation s...
NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation [0.03%]
髓系细胞中由NIK驱动的IL-23生成是自身免疫炎症发病的关键因素
Nishada S Ramphal,Xinyuan Liu,Ilaria Palagi et al.
Nishada S Ramphal et al.
NIK (Map3k14) is a central regulator of noncanonical NF-κB signaling and immune homeostasis. Mutations in this kinase are linked to autoimmune disorders, including multiple sclerosis (MS). Both germline and T cell-specific deletion of NIK ...
Central neurons encode interleukin-1β signals and mediate stress-induced inflammation [0.03%]
中枢神经元编码白细胞介素-1β信号并介导应激诱导的炎症反应
Okito Hashimoto,Tyler D Hepler,Aisling Tynan et al.
Okito Hashimoto et al.
The brain encodes and stores information about peripheral inflammation and can directly recapitulate prior inflammatory responses. However, whether individual cytokines activate specific neural circuits to produce distinct physiological res...
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation [0.03%]
PI3Kδ-Foxo1-FasL信号放大环重新布线CD4+T细胞信号传导和分化
Dominic P Golec,Pedro H Gazzinelli-Guimaraes,Daniel Chauss et al.
Dominic P Golec et al.
While inputs regulating CD4+ T helper (Th) cell differentiation are well defined, the integration of downstream signaling with transcriptional and epigenetic programs that define Th lineage identity remains incompletely resolved. PI3K signa...
Immune checkpoint inhibitor-induced myocarditis is dependent on CD8 T cell-derived TNF and TNFR2 signaling [0.03%]
免疫检查点抑制剂诱导的心肌炎依赖于CD8 T细胞衍生的TNF和TNFR2信号转导
Kathrynne A Warrick,Anne Katrine Z Johansen,Mengchi Jiao et al.
Kathrynne A Warrick et al.
Immune checkpoint inhibitors (ICIs) improve cancer survival but can trigger immune-related adverse events. Among these, fulminant myocarditis is an often fatal complication with limited therapies. We developed a mouse model employing cardio...
Lawrence P Kane
Lawrence P Kane
In this issue of JEM, Golec et al. (https://doi.org/10.1084/jem.20252154) report that a mutation of PI-3 kinase underlying activated PI3K δ syndrome (APDS) impairs type 2 immunity. Surprisingly, mice with this mutation have disordered resp...
Hao Shi,Hongbo Chi
Hao Shi
Mapping the causal circuits that shape the phenotypic and functional landscape of immune cells remains a formidable challenge. Recent advances in pooled CRISPR-based screens, coupled with multiplexed single-cell profiling and imaging-based ...
IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself [0.03%]
干扰素诱导的人类巨噬细胞记忆由细胞因子信号的持久性维系
Aleksandr Gorin,Siyue Niu,Noa Harriott et al.
Aleksandr Gorin et al.
Macrophages, as key sentinel cells of the innate immune system, can retain memory of prior stimulus exposure. IFNγ plays a central role in maintaining trained immunity in vivo and can induce potent memory in macrophages. Such memory is ass...