Aenne Harberts,Bernd Schnabl
Aenne Harberts
Alcohol-associated organ damage is a major cause of morbidity and mortality worldwide, with the liver being the primarily affected organ. Emerging evidence highlights the gut microbiota as a key driver in alcohol-associated liver disease. C...
Folliculin deletion in the mouse kidney results in cystogenesis of the loops of Henle via aberrant TFEB activation [0.03%]
囊泡素在小鼠肾脏中的缺失通过TFEB活化异常导致亨勒袢囊肿形成
Ola Shalaby,Tomoko Ohmori,Koichiro Miike et al.
Ola Shalaby et al.
The mammalian kidney contains numerous nephrons connected to the collecting ducts, and each nephron consists of a glomerulus, a proximal tubule, the loop of Henle (LoH), and a distal tubule. Folliculin (FLCN) is a causative gene for Birt-Ho...
Super-resolution microscopy reveals alterations in clathrin structure in human cancer tissue [0.03%]
超分辨率显微镜揭示了人类癌组织中网格蛋白结构的变化
Alan Greig,Rui Henrique,Boyu Xie et al.
Alan Greig et al.
Super-resolution microscopy holds great promise for detailed structural analysis of proteins yet its application in the investigations of protein structures in situ remains sparse. Clathrin-coated pit-mediated endocytosis (CME) plays a key ...
Metabolic dysfunction-associated steatotic liver disease in patients and mouse with Wilson's disease [0.03%]
Wilson病患者和小鼠中的代谢功能异常相关脂肪性肝病
Zixuan Wang,Qingyang Xu,Mengyu Wang et al.
Zixuan Wang et al.
Wilson's Disease (WD) is a copper metabolism disorder caused byATP7Bgene mutations, and hepatic steatosis is not uncommon in WD. Therefore, we investigated the effects of ATP7B deficiency and/or a high-fat diet (HFD) on the development of s...
Nitric Oxide may Adversely Affect the Metabolism and Viability of Retinal Organoids Derived from Patients with Leber Hereditary Optic Neuropathy [0.03%]
一氧化氮可能对莱伯遗传性视神经病变患者衍生的视网膜类器官的代谢和生存产生不利影响
Fumio Takano,Megumi Kitamura,Kaori Ueda et al.
Fumio Takano et al.
Leber hereditary optic neuropathy (LHON) is a bilateral optic neuropathy associated with mitochondrial DNA (mtDNA) mutations characterized by parapapillary telangiectasia during the acute phase. However, its precise mechanism remains unclea...
Early endosome disturbance and endolysosomal pathway dysfunction in Duchenne muscular dystrophy [0.03%]
杜氏肌营养不良中早期内体紊乱和内溶酶体通路功能障碍
Julie Chassagne,Nathalie Da Silva,Ines Akrouf et al.
Julie Chassagne et al.
Duchenne muscular dystrophy (DMD) is a lethal dystrophy characterized by the progressive loss of muscle fibers caused by mutations in DMD gene and absence of the dystrophin protein. While autophagy and lysosome biogenesis defects have been ...
Correction [0.03%]
改正
Pharmacological inhibition of glutamate dehydrogenase 1 (GLUD1) improves functional recovery of neuromuscular junctions and muscle function in Duchenne muscular dystrophy [0.03%]
谷氨酸脱氢酶1(GLUD1)的药理学抑制可改善杜氏肌营养不良神经肌肉接头和肌肉功能的恢复
Andreia Pereira-Nunes,Ummi Ammarah,Min Shang et al.
Andreia Pereira-Nunes et al.
Presynaptic terminals of neuromuscular junctions (NMJs) are sensitive to glutamate, which contributes to NMJ plasticity and synaptic neurotransmission. However, the effect of glutamate on neurotransmission and its pharmacological modulation...
The angiofibrotic switch in retinal and choroidal vascular diseases: mechanistic drivers of angiogenesis and endothelial-mesenchymal transition [0.03%]
视网膜和脉络膜血管疾病中的血管纤维化转变：血管生成及内皮-间充质转化的机制驱动因素
Fergus C McLellan,Kelvin Huang,Elizabeth Wong et al.
Fergus C McLellan et al.
The angiofibrotic switch refers to the pathological transition from active angiogenesis to fibrosis, a process that contributes to disease progression in retinal and choroidal neovascular diseases such as age-related macular degeneration (A...
Exploratory study of prognostic plasma biomarkers in patients with pulmonary arterial hypertension [0.03%]
肺动脉高压患者预后血浆生物标志物的探索性研究
Yukimitsu Kuwabara,Tetsuro Yokokawa,Sarah-Eve Lemay et al.
Yukimitsu Kuwabara et al.
Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary vascular lumen occlusion, ultimately leading to right ventricular failure and death. Risk stratification is essential for the management of patients with PAH. S...