Visible-Light-Induced Comprehensive Carboxylation of Benzyl Halides with CO2 via Halogen Atom Transfer [0.03%]
光促进的卤素原子转移自由基反应实现CO2与芳基卤化物的羧基化反应
Taito Watanabe,Tomoha Kagawa,Yutaka Saga et al.
Taito Watanabe et al.
Conventional photocatalytic methods for the carboxylation of benzyl halides with CO2 are typically limited to specific halides. Herein, we report a general visible-light-driven protocol using a tertiary amine-mediated halogen atom transfer ...
Sulfonium Salt-Mediated Bisthiolation of Terminal Alkynes to Access Symmetrical and Nonsymmetrical Z- 1,2 - Dithioalkenes [0.03%]
通过硫
Sha Peng,Xiang-Qin Xu,Ding Luo et al.
Sha Peng et al.
In this study, we report an efficient one-pot bisthiolation reaction of terminal alkynes, which enables the regio- and stereoselective synthesis of diverse symmetrical and nonsymmetrical (Z)-1,2-dithioalkenes with wide substrate scope and e...
Organocatalytic Asymmetric [5 + 3] Domino Annulation: Direct Access to Enantioenriched Eight-Membered Bridged Dihydroazocino[4,5- b]indolizines [0.03%]
有机催化不对称[5+3]级联环化反应：直接合成富集对映体的八元桥环二氢吖辛因并吲哚氮杂环化合物
Yuan-Yuan Cheng,Xue-Cheng Shao,Qi-Jian Ni
Yuan-Yuan Cheng
We present here a chiral phosphoric acid (CPA)-catalyzed formal [5 + 3] annulation reaction of ortho-indolizinyl anilines with chalcones. This intriguing Schiff-base/Friedel-Crafts domino cyclization enabled the direct and efficient synthes...
Ag2O/TBAI Initiated Nucleophilic Difluoromethylation of Carbonyl Compounds with Me3SiCF2H [0.03%]
三甲基硅烷二氟甲基化碳
Mingyu Liang,Qingqing Yang,Min Kou et al.
Mingyu Liang et al.
The direct nucleophilic difluoromethylation of carbonyl compounds with Me3SiCF2H initiated by Ag2O/TBAI at room temperature is described. The moisture-tolerant method enables difluoromethylation of a broad range of carbonyl compounds (inclu...
Pd-Catalyzed Ring-Opening of Cyclopropenes for Alkenylation of Phenols: Access to Tetrasubstituted Alkenyl Ethers [0.03%]
钯催化环丙烯开环制备酚类茋化合物的新方法
Yue-Jie Niu,Shutao Wang,Wei-Hua Wang et al.
Yue-Jie Niu et al.
This study reports a novel Pd-catalyzed ring-opening of cyclopropenes for the alkenylation of phenols. Proceeding under mild conditions with high atom economy, the reaction enables the synthesis of diverse tetrasubstituted alkenyl ethers in...
One-Step Biomimetic Synthesis of the Alkaloids Karachine, Valachine, and Sinometumine E [0.03%]
一步生物合成生物碱karachine、valachine和sinometumine E
Alexander A Fadeev,Amálie Vanoušková,Martin Kotora
Alexander A Fadeev
An efficient one-step synthesis of the protoberberine alkaloids karachine, valachine, and sinometumine E is described. This transformation relies on the biosynthetic hypothesis featuring vinylogous aldol, Michael, and Mannich addition react...
Formal Reductive Amination of Carboxylic Acids via Iron-Catalyzed Photoredox Decarboxylative α-Aminomethylation [0.03%]
铁光氧化还原催化羧酸的去羧基α-氨基甲基化及重氮
Jinxi Huang,Donghui Xing,Xiaohong Li et al.
Jinxi Huang et al.
Here we report an iron-catalyzed photocatalytic protocol utilizing ligand-to-metal charge transfer (LMCT) for efficient decarboxylative reductive amination to synthesize tertiary alkylamines. The method employs readily available carboxylic ...
Synthesis of Insulin-desB30 Analogs via an Enzymatically Removable N-Terminal Solubilizing Tag [0.03%]
通过酶可拆解的N-端溶剂化标签合成desB30胰岛素类似物
Yuankun Dao,Terra Lin,Ngoc Le Bich Tran et al.
Yuankun Dao et al.
Chemical synthesis enables rapid access to designed insulin analogs, but the efficiency is hindered by the insulin A-chain's poor solubility. We report a streamlined route using direct Fmoc-SPPS of a native A chain aided by a temporary poly...
Ene-Allenes: Access from Dialkynes by an Intramolecular anti-Carbopalladation Cascade [0.03%]
二炔分子内的反式钯催化卡宾加成串联反应合成Ene-Allene化合物
Pedram Kalvani,Catherine Vanbel,Heinrich F von Köller et al.
Pedram Kalvani et al.
Herein, an intramolecular palladium-catalyzed cascade reaction is reported consisting of both formal anti-carbopalladation and syn-carbopalladation of internal alkynes. This process leads to two new carbon-carbon bonds across the first doub...
Electrochemical Cross-Coupling of P(O)-H with Thioesters: Green Synthesis of Phosphorothioates [0.03%]
P(O)-H与硫酯的电化学交叉偶联：磷硫酸酯的绿色合成
Lihua Huang,Fanhua Meng,Wenying Guo et al.
Lihua Huang et al.
An efficient and eco-friendly electrochemical strategy enables the metal-, base-, and oxidant-free cross-coupling between thioesters and P(O)-H species for the construction of P-S bonds. The reaction proceeds under mild conditions and has a...