Organocatalytic Asymmetric [5 + 3] Domino Annulation: Direct Access to Enantioenriched Eight-Membered Bridged Dihydroazocino[4,5- b]indolizines
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We present here a chiral phosphoric acid (CPA)-catalyzed formal [5 + 3] annulation reaction of ortho-indolizinyl anilines with chalcones. This intriguing Schiff-base/Friedel-Crafts domino cyclization enabled the direct and efficient synthesis of enantioenriche... ...
