Ag2O/TBAI Initiated Nucleophilic Difluoromethylation of Carbonyl Compounds with Me3SiCF2H
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The direct nucleophilic difluoromethylation of carbonyl compounds with Me3SiCF2H initiated by Ag2O/TBAI at room temperature is described. The moisture-tolerant method enables difluoromethylation of a broad range of carbonyl compounds (including aldehydes, keto... ...
