NHC-Catalyzed Access to Benzoxazepinones via Aromatization-Driven Rearrangement [0.03%]
镍催化的芳构化驱动重排反应构建苯并噁塞庚酮类化合物
Jun Sun,Guan-Xin Hu,Yu-Lei Yuan et al.
Jun Sun et al.
Benzazepine derivatives, including benzoxazepines, constitute a privileged class of nitrogen-containing medium-sized heterocycles with significant pharmaceutical relevance. Herein, we report a carbene-catalyzed strategy for the efficient co...
Trifunctionalization of Aryl Iodides Involving Three C-H Activations via Palladium/Norbornene Catalysis [0.03%]
钯/氮杂环烯烃催化三甲基嵌入反应实现芳基碘
Zhengrui Zhou,Chenmeng Sun,Ting Zhong et al.
Zhengrui Zhou et al.
Herein, we report a palladium/norbornene-catalyzed trifunctionalization of ortho-unsubstituted aryl iodides involving three C-H activations. This transformation employs anhydrides and benzyl bromides as different electrophiles to achieve or...
Regioselective Radical 1,4-Difunctionalization of 1,3-Cyclohexadiene via NHC Catalysis [0.03%]
N-杂环卡宾催化环己烯的区域选择性自由基双官能化反应
Yiwen Yin,Jianquan Feng,Liya Wang et al.
Yiwen Yin et al.
1,4-Difunctionalized cyclohexane is not only a useful building block in organic synthesis but also represents an important structural motif in a wide range of bioactive molecules. Herein, we report an unprecedented NHC-catalyzed three-compo...
β-Sulfinimidoyl Esters as Sulfenamide Anion Precursors for Accessing Aza-Sulfur Stereogenic Centers [0.03%]
β-亚磺酰亚胺酯作为亲核硫烯酰胺
Linge Huai,Yu Lan,Wanxing Xiang et al.
Linge Huai et al.
This study reports the design and application of a class of β-sulfinimidoyl esters as sulfenamide anion precursors for constructing aza-sulfur stereocenters. These compounds were effectively utilized in a pentanidium-catalyzed asymmetric s...
Na Eun Kim,Seung Jun Lee,So Won Youn
Na Eun Kim
We report a regiodivergent and stereoselective hydrothiolation of ynamides, enabling access to α- or β-aminovinyl sulfides with complete stereocontrol under mild and sustainable conditions. Notably, this study introduces the first example...
Biosynthesis of Trichobisabolins Involves a UbiA-Type Terpene Cyclase for trans-Zingiberenol Generation and a Single Cytochrome P450 Catalyzing the γ-Butenolide Formation from an Isoprene Unit [0.03%]
毛姜黄素生物合成涉及UbiA型倍半萜环化酶介导的反式zingiberenol生成和一个单一细胞色素P450介导的异戊烯单元γ-丁内酯形成
Cheng Shen,Rui-Ting Guo,Lin Chen et al.
Cheng Shen et al.
Through genome mining, a conserved biosynthetic gene cluster from the biocontrol Trichoderma species was identified and characterized to be responsible for the biosynthesis of γ-butenolide-containing sesquiterpenoid trichobisabolin B. The ...
Total Synthesis of WS9326B via a Bioinspired Macrolactonization Strategy [0.03%]
通过生物启发的宏环化策略完成WS9326B的全合成
Seung Hyun Choi,Seok Beom Lee,Junhwa Hong et al.
Seung Hyun Choi et al.
WS9326B (1) is a cycloheptadepsipeptide isolated from Streptomyces sp. SNM55 and is distinguished by its rare (Z)-pentenyl cinnamic acid side chain and notable antiangiogenic activity. Herein, we report its total synthesis through a bioispi...
Palladium-Catalyzed Enantioselective Intramolecular C-H Arylation of o-Chloroaroylferrocenes Enabled by a Chiral Bidentate Ferrocenyl Phosphine-Pyridine Ligand [0.03%]
手性双齿菲咯啉磷-吡啶配体促进的氯代菲啰啉芳基酮的钯催化不对称 intramolecular C-H 氧化芳构化反应
Shuai-Xi Li,Xiang-Ping Hu
Shuai-Xi Li
A palladium-catalyzed enantioselective intramolecular C-H arylation with unactivated aryl chlorides has been realized. The reaction proceeds on a range of differentially substituted o-chlorobenzoylferrocenes, thus leading to structurally di...
Photoelectrocatalytic Chlorothiocyanation of Unactivated Alkenes via Ligand-to-Metal Charge Transfer [0.03%]
基于配体到金属电荷转移的非活化烯烃的光电催化解硫氰基化反应
Jin Zhang,Yong Liu,Lin-Bao Zhang et al.
Jin Zhang et al.
The difunctionalization of unactivated alkenes has widespread applications in organic synthesis. However, the selective introduction of two different functional groups remains challenging. We herein report a photoelectrochemical chlorothioc...
Asymmetric Electrophilic Amination of Calix[4]arene Amines: Rapid Assembly of Inherently Chiral Diamine Frameworks [0.03%]
卡拜四胺的不对称亲电子氨化反应：固有手性二胺框架结构的快速组装
Xue Gong,Lu Zhang,Xuannan Liu et al.
Xue Gong et al.
This study reports a chiral phosphoric acid (CPA)-catalyzed asymmetric electrophilic amination of calix[4]arene amines, enabling the first synthesis of inherently chiral diamines with distinctive structural features. The method delivers hig...