Palladium(II)-Catalyzed [3 + 2] Annulation of Aromatic Triflamides via Maleimide-Relayed Dual C-H Activation Process [0.03%]
钯催化芳香族三氟甲磺酰胺通过马来酰亚胺介导的双重活性氢过程的[3+2]环化反应
Trisha Chakraborty,Masilamani Jeganmohan
Trisha Chakraborty
A palladium-catalyzed [3 + 2] annulation of substituted aromatic triflamides with maleimides affording tricyclic heterocycles bearing a free NHTf group in a highly atom- and step-economical manner has been developed. Quinoxaline serves as t...
Halogen Atom Transfer (XAT)-Enabled Transition-Metal-Free Radical Annulation for the Construction of Phenanthrene-Derived Polycyclic Aromatic Hydrocarbons (PAHs) [0.03%]
无金属自由基环化反应构建菲蒽类多环芳香烃化合物
Chen Zhou,Pei-Shang Li,Xue-Qing Wang et al.
Chen Zhou et al.
A transition-metal-free radical annulation strategy enabled by halogen atom transfer (XAT) has been developed for the direct construction of phenanthrene-derived polycyclic aromatic hydrocarbons (PAHs) from 2-iodobiaryls and terminal alkyne...
Chemoselective Methionine Bioconjugation with Hydroxylamine Esters for Peptide/Protein Modifications [0.03%]
用于肽/蛋白质修饰的选择性甲硫氨酸生物接合的羟胺酯方法
Man Li,Tianyang Wang,Linfeng Chen et al.
Man Li et al.
Bioconjugation is a powerful strategy and tool to realize the pluripotency of proteins and peptides by allowing access to novel biomolecular scaffolds. Methionine, because of its unique thioether functional group with good nucleophilicity, ...
Mechanistic Insights into the Regioselective Defluorofunctionalization of Trifluoromethylanilines via Photocatalytic SET: A Combined Experimental and Computational Study [0.03%]
光催化单电子转移驱动的三氟甲基芳胺的选择性缺氟官能团化反应：实验和计算相结合的研究
Ting Long,Kazuumi Fujioka,Yahui Wang et al.
Ting Long et al.
We report a photocatalytic method for the selective defluorofunctionalization of trifluoromethylanilines, enabling the synthesis of structurally diverse difluoromethylene-containing aza-heterocycles with broad functional group tolerance. A ...
Construction of Benzothiophene-Fused 1,2,4-Triazocines via a Skeletal Editing Strategy and DFT Study on the Reaction Mechanism [0.03%]
基于骨架编辑策略构建苯并噻吩稠合的1,2,4-三氮杂偶酰类化合物及反应机理的DFT研究
Wenyang Wang,Wenlei Zeng,Qingsong Deng et al.
Wenyang Wang et al.
A series of benzothiophene-fused 1,2,4-triazocines were successfully synthesized through a one-pot skeletal editing strategy. The synthesis commenced with a [4 + 3] cycloaddition reaction to afford a benzothiophene-fused 1,2,4-triazepane in...
Photoredox-Mediated C-N Bond Cleavage Enables Synthesis of Tetra-Substituted Olefins via Reductive Radical-Polar Crossover [0.03%]
光氧化还原介导的C-N键断裂通过还原性自由基极性交叉合成四取代烯烃
Jianchen Zhang,Xiangwen Xu,Denghui Ma et al.
Jianchen Zhang et al.
Synthesizing all-carbon tetra-substituted olefins is challenging due to steric hindrance. Herein, we report a concise photoinduced radical aryl migration strategy for accessing these valuable structures with excellent stereoselectivity unde...
Catalyst-Free [3 + 2] Cycloaddition of Benzimidazole Esters and Quinone Esters: Divergent Synthesis of N-Heterocycles [0.03%]
无催化剂条件下苯并咪唑酯和茋四氟硼酸盐的[3+2]环加成反应：N-杂环化合物的发散合成
Si-Chao Wu,Shi-Jie Liu,Fu-Cai Rao et al.
Si-Chao Wu et al.
Herein, we disclose a catalyst-free [3 + 2] cycloaddition of benzimidazole esters and quinone esters for the efficient and atom-economical construction of benzo[d]imidazol-2-ylidene-2,3-dihydrobenzofurans in good to excellent yield with exc...
One-Pot Iodination and Giese Addition of Glycosyl Esters for the Synthesis of C-Alkyl Glycosides [0.03%]
单锅碘化和甘塞反应合成C-烷基糖苷
Junli Ao,Jun Yang,Xiyue Zhang et al.
Junli Ao et al.
We report a one-pot protocol for the efficient synthesis of C-alkyl glycosides from bench-stable and readily available glycosyl esters. This method integrates iodination and radical addition with activated alkenes in a single operation, off...
Photocatalyzed Nitrene Insertion into C-O Bonds: Access to Benzisoxazoline-3-ones [0.03%]
光催化氮烯与C-O键的插入反应：苯并异异噁唑啉-3-酮的合成路径研究
Lu Kang,Yuqiang Liu,Lili Duan et al.
Lu Kang et al.
The first photoinduced formal nitrene insertion into C-O bonds is established with sulfilimines as free nitrene precursors, providing facile access to N-substituted benzisoxazoline-3-ones under mild and additive-free conditions. DFT calcula...
Atroposelective Cobalt-Catalyzed Decarbonylative Transannulation of Phthalimides and Alkynes [0.03%]
钴催化菲咯啉
Xuying Xia,Cunwei Zheng,Yunfei Hang et al.
Xuying Xia et al.
Considering the crucial role of chiral nitrogen-containing heterocycles in drug discovery, the enantioselective editing of readily available phthalimides into value-added chiral scaffolds is of great interest but remains an unexplored field...