Cobalt-Catalyzed Asymmetric 1,4-Reduction of α,β-Unsaturated Nitriles with HBpin [0.03%]
钴催化α,β-不饱和腈与HBpin的不对称1,4-加成反应
Li Ma,Zhaolin Wang,Chenggong Zheng et al.
Li Ma et al.
A series of novel AAO ligands were synthesized and employed in the cobalt-catalyzed asymmetric 1,4-reduction of α,β-unsaturated nitriles with HBpin, affording β-stereogenic alkyl nitriles with high enantioselectivities. This protocol can...
Divergent Annulation of Isoindolinone-Derived Propargyl Alcohols for the peri-Selective Synthesis of Spirofuran-Isoindolinones and Furanylisoindolinones [0.03%]
异吲哚啉酮衍生物丙炔醇的发散型环化反应及其螺缩酮类化合物的 peri-选择性合成
Yan Yu,Yue Zhou,Zhong-Kun Yang et al.
Yan Yu et al.
We describe a peri-selective synthesis of spirofuran-isoindolinones and 3-furan-2-ylisoindolinones through cascade annulation of cyclohexandiones or their surrogates with isoindolinone-derived propargyl alcohols. Using this methodology, two...
Organocatalytic Enantioselective Addition of 3-Aryloxindoles to Ethenesulfonyl Fluoride [0.03%]
有机催化下3-芳基氧吲哚与乙烯磺酰氟的不对称加成反应
Álvaro Castilla-Mocholí,Marc Montesinos-Magraner,Iñaki Fernández-Yagüe et al.
Álvaro Castilla-Mocholí et al.
We report the synthesis of chiral sulfonyl fluorides bearing a carbon quaternary stereocenter. A commercially available organocatalyst (DHQD)2AQN enables the enantioselective addition of 3-substituted oxindoles to ethenesulfonyl fluoride (E...
Pristine Facet of Alkynyl-Prins Vinyl Carbocations for the Functionalization of Inactivated C(sp3)-H Bonds: A Highly Selective [1,5]-Hydride Migration vs. Concerted C-H Insertion [0.03%]
用于活化惰性C(sp³)-H键的功能化：高选择性的[1,5]氢负离子迁移与分步C-H插入反应机制中的纯净烷基-普林斯乙烯基碳正离子机理研究
Surabhi Mishra,Debayan Roy,Beeraiah Baire
Surabhi Mishra
Selective functionalization of inactivated C(sp3)-H bonds is an important and useful strategy; at the same time, it is a very challenging task due to the presence of similar C(sp3)-H bonds in a single organic molecule. Herein we report an u...
Leveraging Long-Range Nuclear Magnetic Resonance Correlations to Confirm Boronic Acid Protection [0.03%]
利用长程核磁共振相关性确认硼酸保护基的作用
Tristan Maschmeyer-Tombs,David J Russell,Jessica L Ochoa et al.
Tristan Maschmeyer-Tombs et al.
The use of boronic acid esters is prevalent in modern synthetic chemistry. However, confirming the protection of boronic acids using chromatographic, spectrometric, and spectroscopic methods can be challenging. In this study, we successfull...
Selective Conversion of Esters to Ketones via β-Ketosulfone Intermediates [0.03%]
通过β-酮磺酸酯中间体选择性地将酯转化为酮
Ethan Fung,Patrick S Fier
Ethan Fung
The conversion of esters to ketones is a fundamental transformation in organic chemistry, which is often achieved through multistep approaches. Building on our previous work using sulfinates as traceless activating groups, we report a more ...
Synthesis of gem-Diarylcyclobutanes via Palladium-Catalyzed Ring Expansion of Arylidenecyclopropanes with Anilines [0.03%]
钯催化下芳基环丙烷与苯胺的开环扩环反应合成对称二芳基环丁烷化合物
Chunchen Yuan,Wenlong Zhang,Weizhi Zang et al.
Chunchen Yuan et al.
gem-Disubstituted cyclobutanes are essential synthetic building blocks, and the development of synthetic methodologies remains a focal yet challenging frontier in organic chemistry. This study describes a palladium-catalyzed ring enlargemen...
Photoinduced Multicomponent Sulfonylsulfination of Alkenes via Aromatization-Driven Deconstructive and Radical-Polar Crossover Cyclization Strategies [0.03%]
基于芳香化的拆分交叉环化策略及自由基极性交叉反应的烯烃多组分磺酰硫酸酯化研究
Wenchao Gao,Yong Teng,Kexin Huang et al.
Wenchao Gao et al.
A facile methodology, consisting of photoenabled multicomponent coupling of alkenes, spiro-dihydroquinazolinones, and DABSO, is described. This protocol features deconstruction-cyclization efficiency, functional group tolerance, and mild an...
Visible-Light-Driven C(sp3)-H Bond Carboxylation of Benzyl Amines with CO2 for the Synthesis of α-Amino Acids [0.03%]
苯胺的可见光诱导C(sp³)−H键羧基化反应合成α-氨基酸
Wenwen Cui,Bin Li,Baiquan Wang
Wenwen Cui
α-Amino acids are vital structural motifs in both bioactive compounds and synthetic building blocks. However, the photocatalytic synthesis of α-amino acids directly from C(sp3)-H bonds and CO2 is a long-standing challenge. Here we report ...
Synthesis of Aldehyde-Based Acrylonitrile-Bonded Line Polymers via Selective Acetonitrile Coupling Reaction on Surface [0.03%]
基于甲醛的丙烯腈接枝线型聚合物的合成：表面选择性乙腈偶联反应
Zhibiao Chen,Jianchen Lu,Wei Xiong et al.
Zhibiao Chen et al.
Acrylonitrile serves as a key building block in π-conjugated polymers. Conventional solution-based synthesis often leads to the loss of aldehyde (CHO) groups, limiting functionalization. We designed aldehyde-/cyano-functionalized precursor...