Cobalt-Catalyzed Asymmetric 1,4-Reduction of α,β-Unsaturated Nitriles with HBpin
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A series of novel AAO ligands were synthesized and employed in the cobalt-catalyzed asymmetric 1,4-reduction of α,β-unsaturated nitriles with HBpin, affording β-stereogenic alkyl nitriles with high enantioselectivities. This protocol can be scaled to gram q... ...
