Copper/N-Heterocyclic Carbene Cooperatively Catalyzed Remote Asymmetric ε-Alkylation of Yne-Thiophene Esters with Enals [0.03%]
铜/氮杂环卡宾协同催化炔硫醚酯与烯醛的远程不对称ε-烷基化反应
Zhaoliang Ge,Su-Na Guan,Hao Xu
Zhaoliang Ge
A highly enantioselective Cu/NHC cooperative catalytic system was developed for the remote ε-alkylation of yne-thiophene esters with enals. The dual catalysis couples a chiral Cu-PyBox complex, which generates a reactive copper-vinylalleny...
One-Pot Assembly of the Rare Sugar Containing Trisaccharide Repeating Unit of Pseudomonas putida TSh-18 [0.03%]
恶苗菌Tsh-1八糖重复单元的合成
Satyajit Behera,Neema Patel,Aishwarya Shelke et al.
Satyajit Behera et al.
Herein, we report the first total synthesis of the trisaccharide repeating unit of Pseudomonas putida TSh18, achieved through a one-pot glycosylation strategy. The synthesis addresses several challenges, including the synthesis of rare suga...
Lactone-Facilitated Chemoenzymatic Synthesis of Sulfoglucuronosyl Paragloboside Oligosaccharides Bearing the HNK-1 Epitope [0.03%]
用于HNK-1表位的硫代葡萄糖神经酰胺寡糖的乳酸促进的化学酶法合成
Tian Gao,Na Lu,Wenlong Yao et al.
Tian Gao et al.
Herein, we describe a lactone-facilitated chemoenzymatic strategy for the synthesis of sulfoglucuronosyl paragloboside pentasaccharide, sulfoglucuronosyl lactosaminylparagloboside heptasaccharide, and their nonsulfated derivatives. The appr...
Regioselective Markovnikov Hydroalkylation of Unactivated Alkenes Enabled by Photoredox/Nickel Dual Catalysis [0.03%]
光氧化还原/镍双催化未活化烯烃的区域选择性马尔科夫尼可夫羟基烷基化反应
Jie Gao,Liu-Shuo Shi,Xian-Chen He et al.
Jie Gao et al.
Developing practical strategies and a new reaction mode to access the versatile photocatalytic hydroalkylation of olefins with well-controlled regioselectivity remains highly desirable. Herein, we report a photoredox/nickel dual-catalyzed, ...
Asymmetric Electrooxidation of Indoles: Mechanistic Insights from an Enantioselective Bromoradical Addition Pathway [0.03%]
吲哚的不对称电氧化：溴自由基加成途径的机理研究
Changdi Zheng,Yanjun Wan,Yuhua Chen et al.
Changdi Zheng et al.
Oxidative rearrangement of tetrahydro-β-carbolines (THβCs) represents a straightforward route to the synthesis of spirooxindoles. Herein, we disclose the first bromoradical (Br•)-initiated enantioselective electrooxidative rearrangement ...
Serendipitous Assembly of Chiral Face-Rotating Molecular Boxes Directed by Non-Covalent Templation [0.03%]
非共价模板法催化手性面旋转分子箱的偶合组装
Mingyu Cui,Xue Dong,Guoqiang Jiang et al.
Mingyu Cui et al.
A serendipitous outcome in the mandelic acid-mediated imine condensation of a tetraphenylethene-derived tetraaldehyde and tris(2-aminoethyl)amine led to [2 + 4] face-rotating molecular boxes, rather than the expected [6 + 8] cubic cages. Th...
Conjugated Pyrazole-Triazole/Oxadiazole Derivatives via Nitro Functionalization: Toward High-Performance Energetic Materials [0.03%]
通过硝基功能化连接的杂环共轭衍生物：高性能含能材料合成的新策略
Xianfeng Wang,Feng Yang,Shuaijie Jiang et al.
Xianfeng Wang et al.
Through the strategic integration of 3,4-dinitropyrazole with trinitromethyltriazole and oxadiazolone units, two novel asymmetric bicyclic energetic materials, 5-(3,4-dinitro-1H-pyrazol-5-yl)-3-(trinitromethyl)-1H-1,2,4-triazole (DNP-TNF) a...
Chemo-, Regio- and Diastereoselective Synthesis of Azaspiro Tetra-/Pentacyclic Scaffolds with Anticancer Activity [0.03%]
具有抗癌活性的aza螺环四/五元环系化合物的化学、区域和非对映选择性合成
Jia Xu,Xue Li,Jie Lei et al.
Jia Xu et al.
We report an efficient and highly selective synthesis of azaspiro polycyclic scaffolds with excellent chemo-, regio-, and diastereoselectivities. This method exhibits broad substrate scope (44 examples), and the resulting tetracyclic compou...
Electricity-Induced Alkylative Truce-Smiles Rearrangement of N-Arylsulfonylpropiolamides: A Cascade to Functionalized Isothiazolidinones [0.03%]
电诱导的N-芳基磺酰基丙烯酰胺的烷基化TeMan重排反应：合成功能化异噻唑啉酮的新方法
Sébastien Meyer,Aurélie Claraz
Sébastien Meyer
Electrochemistry offers new opportunities for radical Truce-Smiles rearrangement (TSR). Herein, we disclose an electrochemical decarboxylation of redox-active esters that triggers a nondesulfonylative TSR of N-arylsulfonylpropiolamides, del...
Sequential α/β-C-H Functionalization of Monosubstituted Aliphatic Alkenes [0.03%]
单取代亚烷基的顺序α/β-碳氢官能团化反应
Yini Wang,Bingbing Xie,Chengxing Peng et al.
Yini Wang et al.
Monosubstituted alkenes are widely utilized in organic synthesis. Although remarkable progress has been made in chelation-assisted alkenyl C-H functionalization, monosubstituted aliphatic alkene remains a challenging target due to reactivit...