Manipulating Molecular Organizations from "Dimer" to "Tetramer" for Water Evaporation and Thermoelectricity Generation [0.03%]
Xuewei Fu,Shuaijun Zhang,Chengyuan Wang et al.
Xuewei Fu et al.
Four naphthalenediimide-based donor-acceptor structured organic photothermal materials are synthesized with systematically engineered donor-acceptor connecting manners and alkyl chains. The molecular organizations in the solid state are man...
Photocatalytic Transfer of Trifluoromethylcarbenes for X-H Insertion, Oxetane Skeleton Editing, and Alkene Cyclopropanation [0.03%]
Wen-Jie Pan,Dong-Hai Yu,Wei-Guo Cao et al.
Wen-Jie Pan et al.
Although trifluoromethylcarbene chemistry has garnered significant attention for its capacity to concurrently install a CF3 group and forge two new bonds─thus enabling the rapid assembly of molecular complexity─prevailing methods depend a...
Visible Light-Promoted Cascade Cyclization/Allylation of 2-Allyloxyaryl Sulfonium Salts with Morita-Baylis-Hillman Acetates [0.03%]
Ling-Xia Liao,Wen-Tuan Li,Yin-Fang Song et al.
Ling-Xia Liao et al.
A photoinduced radical cascade cyclization/allylation of 2-allyloxyaryl sulfonium salts and Morita-Baylis-Hillman acetates has been developed. The method employs Eosin Y as an organophotocatalyst at room temperature under metal- and oxidant...
Alkoxycarbonylating Reagents from Tetrahydroquinazoline: Enabling Photoredox Catalyst-Free Construction of C(sp2)-C(sp3) and C(sp2)-C(sp2) Bonds [0.03%]
Liulin Jiao,Liu Feng,Hongying Fan et al.
Liulin Jiao et al.
We designed and synthesized new alkoxycarbonylating reagents from tetrahydroquinazolinone through direct photoexcitation to generate alkoxycarbonyl radicals with varying alkyl chain lengths that can add to alkenes triggering cyclization to ...
Diiron Monooxygenase Complex Involved in Antimycin Biosynthesis Transforms Anthraniloyl Thioester into 3-Aminosalicyl Thioester on a Carrier Protein [0.03%]
Yuqiong Zhao,Takayoshi Awakawa,Ikuro Abe et al.
Yuqiong Zhao et al.
Antimycins feature a nine-membered dilactone core and a bioactivity-essential 3-formaminosalic acid. Herein, we demonstrate that the formation of 3-aminosalicylate is catalyzed by AntHIJKL, a multicomponent diiron monooxygenase complex, via...
Synergistic CRISPR-Cas9 Host Engineering and Enzyme Evolution for Enantioselective Synthesis of a Vibegron Pyrrolidine Intermediate [0.03%]
Jinping Bao,Xiaozhi Ju,Han Zhang et al.
Jinping Bao et al.
The stereoselective synthesis of chiral pyrrolidine motifs is essential to vibegron production but remains challenging using conventional chemical routes. Here we report an imine reductase (IRED) catalyzed asymmetric imine reduction to acce...
Bioinspired Total Synthesis of Mulberrofurans G and J, Inethermulberrofuran C, and Mongolicin C from a Common Intermediate [0.03%]
Bangyu Zheng,Mark A Rizzacasa
Bangyu Zheng
The bioinspired total synthesis of mulberry Diels-Alder adducts (MDAAs) mulberrofuran G (4) and J (20), inethermulberrofuran (5), and mongolicin C (6) from the common synthetic intermediate 9 is reported. The approach involved the synthesis...
Cinchona-Functionalized Crown-Ether-Pinioned Calix[4]arene for a Scalable Asymmetric Organocatalytic Aza-Michael Addition Reaction [0.03%]
Kirti Antil,Swati Rani,Apoorva Malik et al.
Kirti Antil et al.
We report an enantioselective aza-Michael addition reaction that is organocatalyzed by cinchonine-functionalized crown-ether-strapped calix[4]arene, which yields the aza-Michael adduct in a high yield (99%) with exceptional enantioselectivi...
Dual Strain-Release Cascade for Accessing sp3-Rich Azetidine-Bicyclopentane Frameworks Bearing Multiple Quaternary Carbon Centers [0.03%]
Vinjamuri Srinivasu,Ajmeera Balaraju,Nakka Ashok Chinni Kumar et al.
Vinjamuri Srinivasu et al.
Azetidines and bicyclopentanes (BCPs) have emerged as valuable bioisosteres for pyridine and benzene rings, driving considerable interest in modern medicinal chemistry. Here, we report a photocatalytic strategy for the efficient and selecti...
Ru(II)-Catalyzed peri-C-H Activation with Strained Alkylidene β-Lactones and β-Lactams: Selective Access to Seven- and Four-Membered Heterocycles [0.03%]
Sudeshna Mondal,Prabhudatta Behura,Suman Dana et al.
Sudeshna Mondal et al.
A Ru(II)-catalyzed peri-C-H activation of α-naphthols with strained alkylidene β-lactones and β-lactams is reported. With alkylidene β-lactones, the reaction proceeds via controlled strain release, favoring an allylic substitution pathw...