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Cinchona-Functionalized Crown-Ether-Pinioned Calix[4]arene for a Scalable Asymmetric Organocatalytic Aza-Michael Addition Reaction

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We report an enantioselective aza-Michael addition reaction that is organocatalyzed by cinchonine-functionalized crown-ether-strapped calix[4]arene, which yields the aza-Michael adduct in a high yield (99%) with exceptional enantioselectivity (99.8%). The cata... ...