Synthesis of γ-Aminophosphonates via Photocatalytic Radical Relay Process [0.03%]
光催化自由基接力过程合成γ-氨基磷onic酸酯
Kui Zhang,Yang Chen,Xueping Zhang et al.
Kui Zhang et al.
γ-Aminophosphonates exhibit promising biological activities and medicinal potential, yet efficient synthetic methods for their preparation remain limited. Herein, we develop a mild and efficient photocatalytic strategy for the construction...
Synthesis of Dibenzo[ a, e]cyclooctatetraenes Enabled by a Palladium-Catalyzed Cross-Coupling Reaction [0.03%]
钯催化交叉偶联反应合成二苯并[a,e]环辛 tetraene
Yinjie Zhu,Ping Lu
Yinjie Zhu
Herein, we report a palladium-catalyzed cross-coupling reaction of sulfonylhydrazones with aryl or alkenyl halides, affording a diverse array of substituted dibenzo[a,e]cyclooctatetraenes featuring planar chirality. Substituents can be effi...
Unified Photoredox Strategy for Selective Access to Hydroisoquinoline and Benzosultam via Tether Modulation of Allylamine [0.03%]
通过亚胺键调控烯胺的多样性导向光氧化还原反应合成异喹啉和苯并磺酰胺化合物
Avik Kr Das,Rabindranath Lo,Soumitra Maity
Avik Kr Das
Hydroisoquinoline and benzosultam motifs represent privileged heterocyclic frameworks with broad pharmacological relevance. We report a divergent photoredox strategy that enables selective access to both scaffolds from a simple precursor. T...
Photoinduced Palladium-Catalyzed Denitrogenative Cyclization of N-Aroyl Benzotriazoles to Phenanthridinones [0.03%]
光促进的钯催化N-芳基苯并三氮唑脱氮环化反应合成菲啶酮类化合物
Daming Liu,Shuo Zhang,Junyu Pan et al.
Daming Liu et al.
A photoinduced Pd-catalyzed denitrogenative cyclization of N-aroyl benzotriazoles was developed. Employing commercially available Pd2(dba)3/XantPhos as the catalyst and PhSiH3 as the additive, a series of N-aroyl benzotriazole derivatives w...
Enantioselective Mannich Reactions of γ,δ-Unsaturated β-Keto Esters and Application in the Synthesis of β'-Amino enones, 2,6-Disubstituted Piperidin-4-ones and (+)-241D [0.03%]
γ,δ-不饱和β-酮酸酯的不对称曼尼希反应及在β'-氨基酸烯酮、2，6-取代的哌啶并-4-酮和（+）-241D合成中的应用
Seerat Virk,Shaikh S Nawaz,Sunil V Pansare
Seerat Virk
Enantioselective, organocatalytic Mannich reactions of γ,δ-unsaturated β-keto esters were developed. The Mannich products are readily decarboxylated to the corresponding amino enones, which can be cyclized to enantiomerically enriched 2,...
Three-Component Alkyl-Diborylmethylation of Alkenes Enabled by Dual Photoredox/Copper Catalysis [0.03%]
光氧化还原/铜催化的烯烃三组分烷基二硼基甲基化反应
Qinqi He,Jiahao Zhang,Die Deng et al.
Qinqi He et al.
A photoredox-catalyzed strategy has been developed for the three-component dicarbofunctionalization of alkenes with aliphatic N-hydroxyphthalimide esters and (diborylmethyl)zinc species under dual photoredox/copper catalysis. This protocol ...
Modular Synthesis of Densely Functionalized Azetidines: Ni-Catalyzed 1,4-Alkylarylation of 1,3-Enynes with 1-Azabicyclo[1.1.0]butanes through Polar-Radical Relay [0.03%]
稠杂取代氮杂环丙烷的模块化合成：镍催化通过极性自由基接力反应实现1,3-炔烯与1-氮杂二环[1.1.0]丁烷的1,4-烷基芳基化反应
Zhengyang Gao,Kuan Zhang,Wentao Zhang et al.
Zhengyang Gao et al.
An efficient synthesis of densely functionalized azetidines has been achieved via a Ni-catalyzed 1,4-alkylarylation of 1,3-enynes using 1-azabicyclo[1.1.0]butanes (ABBs) and arylboronic acids. This three-component reaction offers an easy wa...
Stereoselective Construction of C2-Symmetric Adjacent Bis-α,α'- cis-Disubstituted THF Skeleton via Double Intramolecular Amide Enolate Alkylation: Total Syntheses of (+)-Membranacin and (+)-Squamocin-N [0.03%]
C2对称的相邻双α,α'-反式取代四氢呋喃骨架的立体选择性构建：酰胺烯醇化物与底物两次分子内亲核烷基化反应参与的全合成
Srinivas Batthula,Sudharshan Reddy Sanapalli,Mallesham Samala et al.
Srinivas Batthula et al.
Described herein is the highly stereoselective and concise first asymmetric total synthesis of (+)-squamocin-N (1b) bearing a C15-C24 adjacent bis-tetrahydrofuran (THF) backbone with threo/cis/threo/cis/threo stereochemistry. This approach ...
A Multicatalytic Cascade for the Stereoselective Synthesis of 1,4-Chiral Nitro Alcohols [0.03%]
一类多催化的串联反应用于光学活性1,4-亚硝基醇的合成
Christian Ascaso-Alegre,Álvaro Linacero-Gracia,Patricia Ferreira et al.
Christian Ascaso-Alegre et al.
Artificial cascades offer a powerful strategy to access high-value chemicals efficiently. Here, we report the integration of metal catalysis, organocatalysis, and biocatalysis in a one-pot stereodivergent process to synthesize chiral 1,4-ni...
Carbene-Catalyzed C-H Arylation of Aldehyde-Hydrazone via Radical Cross-Coupling with Iodobenzene [0.03%]
通过自由基交叉偶联碘苯醛希托夫腙的咔贝催化剂催化的C-H芳基化反应
Song Liu,Shunlin Zheng,Ying Zhang et al.
Song Liu et al.
As a unique structure derived from aldehyde/ketone and hydrazine, hydrazone has wide applications in synthetic chemistry. Learning from the recently emerged N-heterocyclic carbene-catalyzed radical coupling of aldehydes, we developed an NHC...