A Multicatalytic Cascade for the Stereoselective Synthesis of 1,4-Chiral Nitro Alcohols [0.03%]
一类多催化的串联反应用于光学活性1,4-亚硝基醇的合成
Christian Ascaso-Alegre,Álvaro Linacero-Gracia,Patricia Ferreira et al.
Christian Ascaso-Alegre et al.
Artificial cascades offer a powerful strategy to access high-value chemicals efficiently. Here, we report the integration of metal catalysis, organocatalysis, and biocatalysis in a one-pot stereodivergent process to synthesize chiral 1,4-ni...
Carbene-Catalyzed C-H Arylation of Aldehyde-Hydrazone via Radical Cross-Coupling with Iodobenzene [0.03%]
通过自由基交叉偶联碘苯醛希托夫腙的咔贝催化剂催化的C-H芳基化反应
Song Liu,Shunlin Zheng,Ying Zhang et al.
Song Liu et al.
As a unique structure derived from aldehyde/ketone and hydrazine, hydrazone has wide applications in synthetic chemistry. Learning from the recently emerged N-heterocyclic carbene-catalyzed radical coupling of aldehydes, we developed an NHC...
Niklas Geue,Kim Greis,Sabrina Omoregbee-Leichnitz et al.
Niklas Geue et al.
Neighboring group participation and remote participation are fundamental concepts in carbohydrate chemistry and are commonly applied to achieve stereocontrol in glycosylation reactions. The corresponding intermediates can be glycosyl cation...
Access to Fused Indolines with a Quaternary N, N'-Aminal Center: Aza-Wacker-Type Cyclization for a Telescoped Reaction Sequence [0.03%]
具有四级N,N'-亚胺基中心的融合吲哚啉类化合物的合成：串联反应序列中的氮杂-瓦克尔型环化反应
Sara Caselli,Amalija Golobič,Fabio Mantellini et al.
Sara Caselli et al.
A highly efficient one-pot sequence has been developed for the rapid construction of fused polycyclic indolines bearing a C2-N,N'-aminal quaternary center. The process, which employs 1,2-diaza-1,3-dienes and 2-substituted indoles as key sub...
Asymmetric Synthesis of Axially Chiral Olefins and Heterobiaryls via Rhodium-Catalyzed C-C Activation and [4 + 2] Annulation [0.03%]
手性铑催化剂的C-C活化/[4+2]环加成串联反应：轴手性烯烃和杂联芳烃的不对称合成
Xuan Zhang,Fen Wang,Xingwei Li
Xuan Zhang
Axially chiral biaryls are privileged scaffolds in chiral ligands, catalysts, and functional molecules. Reported herein is rhodium-catalyzed atroposelective [4 + 2] annulation of benzocyclobutenols with alkynes. The coupling system is chemo...
Direct Indazole Synthesis via Ruthenium(II)-Catalyzed Acceptorless Dehydrogenative Annulation of Alcohols and Arylhydrazines [0.03%]
醇和芳肼经钌催化脱氢偶联反应直接合成吲唑类化合物
Yinyin Chen,Hua Chen,Xueli Zheng et al.
Yinyin Chen et al.
Indazole serves as an important organic synthetic intermediate with significant pharmaceutical activity. Herein, we report the first example of efficiently constructing the indazole framework through an acceptorless dehydrogenative annulati...
Photoinduced Synthesis of S-Aryl Dithiocarbamates and Arylamides via Denitrogenation and CS2/CO Insertion of Aryltriazenes [0.03%]
通过芳基三氮烯的脱氮和CS2 / CO插入光合成S-芳基二硫代氨基甲酸酯和芳胺
Fei Xue,Chenglong Wang,Bin Wang et al.
Fei Xue et al.
The targeted and selective replacement of multiple atoms in a molecule represents a robust strategy for the rapid interconversion of molecular scaffolds. Herein, an efficient strategic atom replacement strategy for synthesizing S-aryl dithi...
Electron Donor-Acceptor Complex-Driven Minisci Reactions of N-Heteroaromatic and Inert C(sp3)-H without Brønsted Acids and External Oxidants [0.03%]
无质子酸和外部氧化剂的电子给体-受体复合物驱动的N-杂芳烃和惰性C(sp3)氢的Minisci反应
Meiqiang Li,Junfeng Yang,Kaikai Qiao et al.
Meiqiang Li et al.
We report a direct Minisci-type reaction of N-heteroaromatics via electron donor-acceptor (EDA) complex photochemistry. This method employs sulfonium salts as versatile electron acceptors to facilitate Minisci Reactions with unactivated C(s...
Electrochemical Radical Allylic Trifluoromethylation of Free Allylic Alcohols with Trifunctional Trifluoromethyl Thianthrenium Salts [0.03%]
三官能 trifluoromethyl thianthrenium 盐与自由烯丙醇的电化学自由基烯丙基 trifluoromethylation反应
Fantao Meng,Hongbin Zhang,Kun Xu et al.
Fantao Meng et al.
The radical allylic substitution of free allylic alcohols remains a challenge. Herein, we report an electrochemical strategy that facilitates the dehydroxylative allylic trifluoromethylation of unprotected allylic alcohols with thianthreniu...
Photodriven Iron-Catalyzed Selective Oxidative Coupling of Benzylic Alcohols to Afford 1,2-Diols under Air [0.03%]
光照铁催化伯醇选择性氧化偶联制备仲二醇类化合物
Tongyu Han,Quansheng Mou,Jinya Li et al.
Tongyu Han et al.
In light of future sustainability and social/environmental well-being, the integration of abundant metal catalysts with cost-effective, readily available oxidants to achieve high-value transformations of chemicals holds significant importan...