Stereoselective Construction of C2-Symmetric Adjacent Bis-α,α'- cis-Disubstituted THF Skeleton via Double Intramolecular Amide Enolate Alkylation: Total Syntheses of (+)-Membranacin and (+)-Squamocin-N
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Described herein is the highly stereoselective and concise first asymmetric total synthesis of (+)-squamocin-N (1b) bearing a C15-C24 adjacent bis-tetrahydrofuran (THF) backbone with threo/cis/threo/cis/threo stereochemistry. This approach features constructio... ...
