Enantioselective Mannich Reactions of γ,δ-Unsaturated β-Keto Esters and Application in the Synthesis of β'-Amino enones, 2,6-Disubstituted Piperidin-4-ones and (+)-241D
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Enantioselective, organocatalytic Mannich reactions of γ,δ-unsaturated β-keto esters were developed. The Mannich products are readily decarboxylated to the corresponding amino enones, which can be cyclized to enantiomerically enriched 2,6-disubstituted pipe... ...
