Electrochemical Radical Addition-Initiated Ring-Opening/Functionalization of 2-Alkylidenecyclobutanols toward γ,δ-Unsaturated Ketone Synthesis [0.03%]
电化学自由基加成引发的2-烯亚甲基 cyclobutanols 开环/官能团化反应制备γ,δ-不饱和酮类化合物
Juan Fan,Huiying Sun,Yanjiang Chen et al.
Juan Fan et al.
γ,δ-Unsaturated carbonyl compounds bearing halogen/sulfonyl groups are valuable in medicinal chemistry, but their efficient synthesis remains a considerable challenge. Here, we report an electrochemical radical addition-initiated ring-ope...
Au(I)/Au(III)-Catalyzed Annulative Addition of Alkynes to Aryl Iodides [0.03%]
金(I)/金(III)催化联芳基碘与末端炔氢的偶联环化反应
Hongyan Liu,Bo Xu
Hongyan Liu
We present a ligand-enabled, gold-catalyzed syn-1,2-carbohetero-functionalization of both internal and terminal alkynes with o-iodo-arylamides. The transformation integrates a tandem oxidative addition and syn-auration, affording a diverse ...
Enantioselective Synthesis of Seven-Membered Bridged Biaryls via Pd-Catalyzed Asymmetric Annulative Allylic Alkylation [0.03%]
钯催化不对称环化偶联反应构建七元桥环茋类化合物
Cong Li,Qijian Ni,Xiaoxiao Song
Cong Li
An enantioselective formal [5+2] annulation strategy for the efficient synthesis of seven-membered bridged biaryls is reported through palladium-catalyzed asymmetric annulative allylic alkylation of o-indolizinyl N-sulfonylanilines with (Z)...
Chemodivergent Multicomponent Reactions of Morita-Baylis-Hillman-Type Yne-allylic Esters with 1,3-Dicarbonyls or Aroylacetonitriles [0.03%]
炔亚甲基马尔科夫尼柯夫烯丙酯与1,3-二羰基化合物或芳基乙腈的化学分化多重组分反应
Chen Huang,Chao-Xu Li,Guang-Jie Wang et al.
Chen Huang et al.
Herein, we introduce Morita-Baylis-Hillman-type yne-allylic esters that serve as novel precursors in a chemodivergent multicomponent reaction platform with carbon-based nucleophiles. SN2″ addition of tertiary amines generates unprecedented...
Palladium-Catalyzed Intramolecular meta-C-H Arylation Assisted by Nitrile Templates Under Microwave-Accelerated Conditions Accessing Fluorene Frameworks [0.03%]
钯催化微波促进条件下氮苷模板化亚胺参与的分子内苯环meta-C-H芳基化反应构建荧蒽框架化合物
Kurella Mounika,Gedu Satyanarayana
Kurella Mounika
Although intermolecular meta-C-H arylation has been thoroughly studied and well established, the intramolecular version of meta-C-H arylation is still largely unexplored and offers exciting opportunities for future research. With these cons...
Copper(II)-Catalyzed Radical-Type Selenium(II)-Nitrogen Exchange Chemistry between Benzoselenazolones and Hydrazines [0.03%]
苯并硒唑酮与胲类化合物的铜催化硒氮交换反应
Jiacheng Pang,Yihong Qu,Jian Lv et al.
Jiacheng Pang et al.
The first radical-type selenium(II)-nitrogen exchange (SeNEx) chemistry was successfully developed, enabling rapid synthesis of diaryl selenides in moderate to excellent yields (46 examples, 21-89%). This chemistry brings arylhydrazines int...
Chiral N, N'-Dioxide/Magnesium(II)-Catalyzed Enantioselective [3,3]-Sigmatropic Rearrangement of 3-Propargyloxyflavones [0.03%]
氮氧化物/镁协同催化的3-丙炔氧基黄酮的对映选择性[3,3]重排反应
Deyang Liu,Cuihua Chu,Yi Li et al.
Deyang Liu et al.
A chiral N,N'-dioxide/Mg(II) catalytic system was developed for the efficient promotion of the enantioselective [3,3]-sigmatropic rearrangement of 3-propargyloxyflavones. Diverse allene-containing 3-propargyloxyflavone derivatives were thus...
Photoredox-Catalyzed Modular Synthesis of ε-Lactams via Acrylamides Cyclization Enabled by Radical-Polar Crossover-Mediated Carbanion Trapping [0.03%]
光氧化还原催化通过自由基极性交叉介导的卡宾阴离子捕获使丙烯酰胺环化以模块化合成ε-内酰胺
Yangjing Xu,Denghui Ma,Haoran Huang et al.
Yangjing Xu et al.
A photocatalytic strategy for the direct synthesis of naphtho-fused ε-lactams from acrylamides is reported. This protocol leverages visible-light-induced single-electron-transfer oxidation of acrylamides to radical cations, followed by int...
Hypervalent Iodine Diazo Esters as C1 Synthons in [3+2+1] Cascade Cyclization: Access to Fully Substituted Pyridines [0.03%]
高价碘代偶氮酯作为C1合成子在[3+2+1]级联环化反应中制备完全取代的吡啶化合物
Di Hu,Chao Pi,Yanqi Li et al.
Di Hu et al.
Fully substituted pyridines are important cores in natural products, functional materials, and pharmaceuticals. Building such a motif usually requires multiple steps, a transition metal as a catalyst, and external additives. Herein, a [3+2+...
Construction of C-S and C-Se Bonds via Deaminative Coupling of Primary Amines [0.03%]
通过一级胺的脱氨基偶联构建C-S和C-Se键
Na Jin,Long Li,Hua Zhang et al.
Na Jin et al.
Herein, we report a versatile and efficient transition-metal-free protocol for the deaminative functionalization of primary alkyl and aryl amines, enabling the construction of sulfides, selenides, alkynes, alkenes, and oxime esters. This me...