Photoredox-Catalyzed Modular Synthesis of ε-Lactams via Acrylamides Cyclization Enabled by Radical-Polar Crossover-Mediated Carbanion Trapping
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A photocatalytic strategy for the direct synthesis of naphtho-fused ε-lactams from acrylamides is reported. This protocol leverages visible-light-induced single-electron-transfer oxidation of acrylamides to radical cations, followed by intramolecular electrop... ...
