Phosphine-Catalyzed Visible-Light-Induced Aminodifluoroalkylation of Alkenes: Access to α,α-Difluoro-γ-lactams [0.03%]
Lanlin Wang,Xiang Lian,Chao Liu et al.
Lanlin Wang et al.
A visible-light-induced, phosphine-catalyzed radical cyclization of α-bromodifluoroacetamides with various olefins has been established for the efficient synthesis of α,α-difluoro-γ-lactams. This protocol offers mild reaction conditions...
Masanobu Ogikubo,Koji Hirano,Yuji Nishii
Masanobu Ogikubo
The ipso-halogenation of arylsilanes offers an attractive approach to access unconventional and synthetically challenging substitution patterns beyond the substrate-dependent regioselectivity of conventional electrophilic halogenation. We d...
Hongchang Tian,Xueqian Wang,Xiao Xiao et al.
Hongchang Tian et al.
We report the development of a novel nickel-hydride catalytic system for the reductive coupling of aryl halides with isoprene under mild conditions, allowing direct access to structurally diverse aryl isopentenyl compounds. The method requi...
P(NMe2)3-Mediated Umpolung (3 + 2) Annulation of β,γ-Unsaturated α-Keto Carbonyls with p-Quinone Methides: Synthesis of Spirocyclopentenyl p-Dienones [0.03%]
Xiang Zhen,Qi-Qiong Yang,Le-Le Meng et al.
Xiang Zhen et al.
A novel umpolung (3 + 2) annulation reaction between β,γ-unsaturated α-keto carbonyls and p-quinone methides mediated by P(NMe2)3 is described, providing a stereoselective approach to the construction of synthetically interesting, densel...
Mikel J Allas,Laura Burchill,Adam W E Stewart et al.
Mikel J Allas et al.
Roseochelins A and B are produced by Phaeobacter inhibens and proposed to arise from algal sinapic acid through combined enzymatic and nonenzymatic steps. We report concise, biomimetic total syntheses mirroring a revised biosynthetic pathwa...
Dan Wang,Xintao Liu,Jinghan Zhang et al.
Dan Wang et al.
Herein, we develop a photocatalytic [4 + 1] annulation of vinyl aziridines with alkyl halides. The reaction appears to experience radical trigger kinetically favored β-scission of the vinyl aziridine C-N bond, generating transient nitrogen...
Jie Gao,Liu-Shuo Shi,Xian-Chen He et al.
Jie Gao et al.
The hydrogenation of olefins, as a vital transformation in synthetic chemistry, has consistently garnered intensive attention in both industry and academia. Herein, a dual photoredox/nickel-catalyzed hydrogenation of alkenes bearing an amid...
Photocatalytic Difluoromethylation Cyclization and Dioxygen Trapping: Access to gem-Difluoro-Quinolines [0.03%]
Lianglong Sun,Xinming Xu,Qilu Li et al.
Lianglong Sun et al.
Herein, a novel photocatalytic 6-exo-trig difluoromethylation cyclization and subsquent domino O2 trap version is described. This protocol allows efficient access to structurally diverse 4-(hydroxymethyl)-gem-difluoro-quinolines under mild ...
Wen-Jie Qiu,Zhiwei Xu,Yu Liu et al.
Wen-Jie Qiu et al.
[70]Fullerene (C70)-fused five-membered-ring lactones were synthesized via manganese(III) acetate (Mn(OAc)3)- or air-promoted protocols. Under Mn(OAc)3-promoted conditions, three isomers 2a-c were obtained. In contrast, the single isomer 2a...
Yosuke Sakamoto,Hayato Nishiguchi,Koji Hirano et al.
Yosuke Sakamoto et al.
Edge-polyhalogenation of PAHs has attracted considerable interest because the resulting halogenated derivatives exhibit characteristics that are notably different from those of the parent hydrocarbons. Nevertheless, direct and selective hal...