Copper-Catalyzed Amination of Polyfluoroarenes via Decarbonylative Metallaphotoredox [0.03%]
铜催化脱羰基金属光氧化还原胺化聚氟芳烃反应
Dan Liu,Juan Hu,Qu Luo et al.
Dan Liu et al.
The development of methods to form anilines has been a long-standing interest in the synthesis field driven by the prevalence of these motifs in natural products, pharmaceuticals, and functional organic materials. Here, a successful protoco...
Electrochemically Driven Decarboxylative Primary Alkylarylation of Alkenes with Aliphatic Carboxylic Acids [0.03%]
电化学驱动的醛酸与烯烃α-位-primary烷基芳基化反应脱羧过程
Meiqun Lu,Enqi Xie,Wenjie Song et al.
Meiqun Lu et al.
Here introduces a novel method for the electrochemical decarboxylative primary alkylarylation of alkenes using quaternary ammonium salts from fatty acids, eliminating the need for external oxidants or metal catalysts to facilitates the effi...
Synthesis of Imidazopyridine- and Indole-Fused Azepinones via an Unusual Friedel-Crafts Alkylation of Chloroacetylated GBB Adducts [0.03%]
通过GBB加成物氯乙酰化的非常规傅克烷基化合成咪唑并吡啶和吲哚稠合氮杂庚酮类化合物
Ashutosh Nath,Jiaming Zhu,Lydia Seki et al.
Ashutosh Nath et al.
A new Friedel-Crafts-type reaction involving the formation and ring expansion of spiro-β-lactam is discovered in the synthesis of imidazopyridine- and indole-fused azepinones. The Groebke-Blackburn-Bienaymé (GBB) reaction adducts undergo ...
Access to Substituted Pyrimidines via Isoxazole Ring Transformation in Three-Component Reactions with Amines and Orthoesters [0.03%]
通过异噁唑环转化在三组分反应中获得取代嘧啶类化合物
Peiyi Jin,Jia Hui Ng,Edward R T Tiekink et al.
Peiyi Jin et al.
The isoxazole ring transformation was effectively applied for the synthesis of diverse pyrimidines by using a three-component reaction of 5-aminoisoxazole-4-carbonitrile with primary amines and orthoesters. The one-pot rearrangement of the ...
N-Heteroaromatic Fused BODIPY Dimers: Ring-Size Effects from Five- to Six-Membered Rings [0.03%]
N-杂芳基稠合BODIPY二聚体：从五元到六元环的环尺寸效应
Yongli Zhang,Hao Guan,Qin Duan et al.
Yongli Zhang et al.
Three BODIPY dimers fused with five- and six-membered N-heterocycles were synthesized via an SNAr and C-H activation strategy. N-Heterocycle size enables precise modulation of electronic delocalization and excited-state character. The six-m...
Deconstructive Alkylation of Unstrained Cyclic Amines via Lewis Base-Boryl Radical-Enabled Spin-Center Shift [0.03%]
路易斯碱/硼自由基介导的自旋中心转移构建未环张力氮杂环化合物中的去构筑式烷基化反应
Gui-Hao Zhang,Zhong-Ping Cai,Tian Ye et al.
Gui-Hao Zhang et al.
Deconstructive alkylation of unstrained cyclic amines is achieved through a boryl radical-enabled spin-center shift (SCS) strategy. Mechanistic studies, including control experiments and DFT calculations, support a pathway involving boryl r...
Deskarene: Single-Molecule Conductance and Mixed-Valence Character of Diferrocene-Based Ladder-Type Conjugated Molecules [0.03%]
基于二茂铁的梯状共轭分子的单分子导电性及混合价特性
Yanxia Huang,Yuanping Li,Na Huang et al.
Yanxia Huang et al.
Ferrocene-anthracene-fused ladder-type molecules (2Fc-anti and 2Fc-syn) were achieved via a C-H activation/annulation strategy. This design extends the π-conjugated system through molecular ladderization, effectively elongating the molecul...
Synthesis of γ-Carbonyl Aliphatic Sulfoxonium Salts via Site-Selective Ring Opening of In Situ Formed 2-Sulfoxonium Cyclobutanone [0.03%]
原位形成2-亚砜环丁酮的定点开环合成γ-羰基脂肪族亚甲𬭩盐
Bingyang Han,Zihui Gong,Zhaofeng Wang
Bingyang Han
We report herein a Rh-catalyzed tandem reaction between a pivaloyl-substituted sulfoxonium-iodonium ylide and diverse nucleophiles, enabling the efficient synthesis of γ-sulfoxonium carbonyl compounds, which were previously inaccessible. T...
A Mild Synthetic Protocol for Conversion of Aldehydes to Nitriles Using a Copper Catalyst and LiHMDS as the Nitrogen Source [0.03%]
一种温和的合成方法：利用铜催化剂和LiHMDS作为氮源将醛转化为腈化合物
Joakim Bøgelund Jakobsen,Xinkai Wu,Markus Staudt et al.
Joakim Bøgelund Jakobsen et al.
Interconversion of functional groups in organic chemistry is a key task. Here we have developed an oxidative transformation of aldehydes to nitriles using lithium bis(trimethylsilyl)amide as a nitrogen source and copper iodide as an inexpen...
Direct Access to SCF3-Substituted 2H-Thiopyrans Via a [4 + 2] Annulation with 1,3-Dienes, AgSCF3, and KI [0.03%]
通过[4+2]环化反应直接获得SCF3取代的2H-噻喃杂环化合物
Kang Guo,Bin Chen,Yongchao Lu et al.
Kang Guo et al.
A [4 + 2] annulation with 1,3-dienes, AgSCF3, and KI has been established, affording a variety of CF3S-substituted 2H-thiopyrans with high chemo- and regioselectivities. The intermediate (CF3S)2C═S is generated in situ via the reaction of ...