Synthesis of Imidazopyridine- and Indole-Fused Azepinones via an Unusual Friedel-Crafts Alkylation of Chloroacetylated GBB Adducts
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A new Friedel-Crafts-type reaction involving the formation and ring expansion of spiro-β-lactam is discovered in the synthesis of imidazopyridine- and indole-fused azepinones. The Groebke-Blackburn-Bienaymé (GBB) reaction adducts undergo N-chloroacylation an... ...
