Access to Substituted Pyrimidines via Isoxazole Ring Transformation in Three-Component Reactions with Amines and Orthoesters
{{output}}
The isoxazole ring transformation was effectively applied for the synthesis of diverse pyrimidines by using a three-component reaction of 5-aminoisoxazole-4-carbonitrile with primary amines and orthoesters. The one-pot rearrangement of the products further exp... ...
