Direct Synthesis of Triarylethynylphosphines from White Phosphorus and Arylacetylidene Lithiums [0.03%]
从白磷和芳基乙炔锂盐直接合成三芳基乙炔基膦
Yu-Zhong Yang,Yu Chen,Xinlei Huangfu et al.
Yu-Zhong Yang et al.
A novel diphenyl diselenide-mediated protocol for the direct synthesis of triarylethynylphosphines from white phosphorus and arylalkynyl lithiums is presented. Employing diphenyl diselenide as the mediator, a catalytic amount of arylalkynyl...
Palladium(0)-Catalyzed Nucleophilic Cyclization of Conjugated Enyne-Carbonyls Leading to Cyclic Allenic Alcohols [0.03%]
钯催化共轭烯炔酮亚胺的亲核环化反应合成环状 allenol 系列化合物
Hirokazu Tsukamoto,Kazuya Ito,Takayuki Doi
Hirokazu Tsukamoto
Conjugated enynes bearing carbonyl functionality undergo alkoxylative, alkylative, and aminative cyclizations under palladium(0) catalysis to afford cyclic allenic alcohols. The reaction affords two diastereomers due to the presence of both...
Photoinduced Smiles Rearrangement of N-Sulfonylpropargylamines for Highly Stereoselective Access to Tetrasubstituted Allylamines [0.03%]
氮磺酰丙烯胺的光诱导斯マイ尔斯重排反应制备四取代高立体选择性的亚氨基茋化合物
Tian-Shu Zhang,Wenchang Zhuang,Shu-Min Lu et al.
Tian-Shu Zhang et al.
Smiles rearrangement enables the migration and structural reorganization of aromatic rings, providing an efficient strategy for the construction of tetrasubstituted alkenes. Despite significant advances, examples of Smiles rearrangements in...
Imidazolidine-Pyrroloimidazolone Pyridine-Cu(OTf)2 Complex Catalyzed Asymmetric Radical Carbo-Esterification [0.03%]
咪唑啉-吡咯并咪唑化合物-吡啶-铜(OTf)₂配合物催化不对称自由基碳酯化反应
Xiao-Bing Wang,Gao-Yang Xu,Ming-Sheng Xie et al.
Xiao-Bing Wang et al.
Highly enantioselective radical carbo-esterification of iodoacetic acid with alkenes was achieved under mild conditions with 5 mol % of a chiral copper complex as the catalyst. With Cu(OTf)2 as Lewis acid and C1-symmetric imidazolidine-pyrr...
Total Synthesis of (+)-Malbrancheamide B Employing a Bioinspired Strategy [0.03%]
运用生物启发策略完成(+)-马尔布拉尚胺B的全合成
M Aurelia Bosi,Radek Pohl,Ullrich Jahn
M Aurelia Bosi
Prenylated indole alkaloids are a class of secondary metabolites isolated from various terrestrial and marine fungi. The common complex structure, featuring a diazabicyclo[2.2.2]octane scaffold fused to a tetrahydrocarbazole unit, and the n...
Chiral Pyridoxamines Featuring Proton-Donating Auxiliary Side Chains for Asymmetric Biomimetic Transamination [0.03%]
具有给电子辅助侧链的手性吡哆胺用于不对称仿生转氨反应
Daqing Sun,Yunfei He,Xinyi Ren et al.
Daqing Sun et al.
Inspired by transaminases, we developed a novel class of chiral pyridoxamine featuring an auxiliary proton-donating side chain. These catalysts exhibited excellent activity and enantioselectivity in the asymmetric transamination of α-keto ...
Synthesis of (S)-Finerenone via Late-Stage Asymmetric Transfer Hydrogenation [0.03%]
通过后期动态动力学拆分策略高效制备(S)-非洛伦酮
Zihao Dai,Jiamu Liu,Naixing Wang et al.
Zihao Dai et al.
Herein, we report a convergent and practical synthesis of the nonsteroidal mineralocorticoid receptor antagonist (S)-finerenone. The present approach incorporates a scalable, chromatography-free method to attain a racemic precursor with an ...
The Electrochemical Functionalization of N-H Bond on N-Heterocycles with Isocyanides to Synthesize Azole Urea Compounds and Methanimines [0.03%]
电化学催化异氰化物与氮杂环N-H键作用合成唑类衍生物
Tan Zhang,Wenhui Wang,Mingqi Chen et al.
Tan Zhang et al.
A selective protocol for the synthesis of azole ureas and diheterocycle substituted methanimines from nitrogenous heterocycles and isocyanides was established under electrochemical reaction conditions. By adjustment of the reaction conditio...
Dokdothiocin, an Anti-Neuroinflammatory Thiopeptide from Streptomyces sp. 20A130 [0.03%]
来自Streptomyces sp. 20A130的抗神经炎噻唑肽 Dokdothiocin
Jihun Park,Son Hung Tran,Keunwan Park et al.
Jihun Park et al.
Dokdothiocin, a ribosomally synthesized and post-translationally modified peptide (RiPP) belonging to the thiopeptide family, was isolated from Streptomyces sp. 20A130. Its structure was elucidated by extensive NMR analyses, high-resolution...
Bioinspired Synthesis of Curtachalasin A and Δ6,12-Curtachalasin N Enabled by Tandem Transannular Epoxyalkene Cyclization and α-Ketol Rearrangement [0.03%]
受启发的合成Curtachalasin A及Δ6,12-Curtachalasin N：由并环环氧烯烃化和α-酮基重排串联反应实现
Hanwei Li,Jiao Yao,Ya Liu et al.
Hanwei Li et al.
Biomimetic syntheses of curtachalasin A (1) and Δ6,12-curtachalasin N (12), a highly oxidized rearranged cytochalasin-type featuring a novel 5/6/6/6 tetracyclic scaffold converted from naturally abundant cytochalasin D containing a 5/6/11 ...