Bioinspired Synthesis of Curtachalasin A and Δ6,12-Curtachalasin N Enabled by Tandem Transannular Epoxyalkene Cyclization and α-Ketol Rearrangement
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Biomimetic syntheses of curtachalasin A (1) and Δ6,12-curtachalasin N (12), a highly oxidized rearranged cytochalasin-type featuring a novel 5/6/6/6 tetracyclic scaffold converted from naturally abundant cytochalasin D containing a 5/6/11 tricyclic skeleton, ... ...