Fully Substituted Cyclobutenes via [2 + 2] Cycloaddition of Ynimines with Cinnamamides [0.03%]
炔亚胺与桂皮酰胺的[2+2]环加成反应合成全取代环丁烯
Haojie Ge,Huimin Jin,Xinyi Chen et al.
Haojie Ge et al.
Cyclobutenes are found in natural products and medicinal chemistry and can be readily functionalized. Herein is presented a straightforward, transition-metal-free [2 + 2] cycloaddition reaction of readily available ynimines with N,N-dimethy...
Humupulusones A and B, Two Skeletally Novel Acylphloroglucinol Derivatives from Humulus lupulus [0.03%]
葎草中两种骨架新颖的酰基松醇 glucinol 衍生物Humupholones A和B
Huaqiang Li,Siqi Li,Gang Li et al.
Huaqiang Li et al.
Two novel acylphloroglucinol derivatives, humupulusones A and B (1 and 2), were isolated from Humulus lupulus. Compound 1, a pair of enantiomers (1a/1b), is the first acylphloroglucinol derivative with a bicyclo[2.2.2] carbon skeleton posse...
Photochemical Synthesis of 1,2-Diazepine-Fused β-Lactams via Staudinger-Type [2 + 2] Cyclization [0.03%]
基于施陶丁格类似物[2+2]环加成的含氮七元杂环并β-内酰胺化合物合成反应
Jules God-Carles,Flavien Bourdreux,Aurélie Damond et al.
Jules God-Carles et al.
Herein, we report a one-pot sequence to prepare 1,2-diazepine fused β-lactams under photochemical irradiation. Hence, α-diazoketones are readily converted to the corresponding ketenes in an additive-free Wolff rearrangement and react with...
A Pd-Catalyzed (6+2) Cycloaddition/Ring-Contraction Relay for Chemodivergent Access to Chiral Spirooxindoles [0.03%]
钯催化（6+2）环加成/环收缩串联反应合成手性螺氧吲哚化合物的新方法
Yu-Jie Li,Jichao Huang,Gao Liu et al.
Yu-Jie Li et al.
Herein, we report a Pd-catalyzed asymmetric (6+2) cycloaddition that directly furnishes indole-fused eight-membered lactones bearing an all-carbon quaternary stereocenter with high efficiency and enantioselectivity. Notably, simple modulati...
Access to Rare d- and l-Hexoses from C1 Nucleophiles via Anomeric Acylation [0.03%]
通过糖环端基酰化反应由C1亲核试剂合成重要的d-和l-型六碳糖异构体化合物
Timothy Davis,Mohit Kumar,Santosh Shelar et al.
Timothy Davis et al.
We report a stereoretentive homologation of C1 anomeric nucleophiles into C1 esters produced in both anomeric configurations, starting from configurationally stable anomeric stannanes and boronic acids. This reaction enabled elaboration of ...
Cu-Catalyzed Reductive Coupling of Allylic and Carbonyl Electrophiles [0.03%]
铜催化下的烯丙基和羰基亲电子试剂的还原偶联反应
Vaughn Beale,Ming Chen
Vaughn Beale
We report herein Cu-catalyzed syntheses of secondary and tertiary homoallylic alcohols. Compared to conventional carbonyl addition with nucleophilic allylation reagents, this process utilizes a reductive coupling strategy in which electroph...
para-Selective C-H Arylation and Alkylation of N-Arylhydroxylamines [0.03%]
N-芳基羟胺的C-H arylation和alkylation反应
Rui-Qiang Jiao,Jingtai Pei,Zhenguo Xi et al.
Rui-Qiang Jiao et al.
The direct para-selective functionalization of arenes is difficult under mild conditions without the use of directing groups and transition-metal catalysts. Here we present a fluorosulfuryl imidazolium triflate-mediated direct para-selectiv...
Electronic Structure Rearrangement via Nitroamine-Nitroimine Tautomerism: Obtaining Thermally Stable and Low-Sensitivity Nitrogen-Rich Nitroamine Energetic Materials [0.03%]
硝胺-亚硝酰胺互变异构体的电子结构重排：获得热稳定性好且安全性高的富氮含能材料
Yizhen Feng,Yaqun Dong,Qiangqiang Liu et al.
Yizhen Feng et al.
This work established a synthetic strategy combining nitroamine-nitroimine tautomerism and intramolecular hydrogen bonding, yielding compound 3 with a zwitterionic structure. Compound 3 (D = 8722 m s-1; P = 29.9 GPa) exhibited detonation th...
Constructing Inter-ring Hydrogen Bonds for High-Performance Energetic Compounds [0.03%]
构建环间氢键以获得高性能含能材料
Zihan Lin,Xudong Xu,Ning Ding et al.
Zihan Lin et al.
The pursuit of both high energy density and stability remains a fundamental objective in energetic material research. Construction of the resonance-assisted hydrogen bond (RAHB) has emerged as a viable strategy for stabilizing bicyclic comp...
Site-Selective Decarboxylative C-H Carbenoid Functionalization Enabled by Pyridotriazole-3-carboxylates [0.03%]
由吡啶三氮唑-3-羧酸酯位点选择性羧基活化C-H卡宾化功能化的研究
Xin Yang,Heng Xu,Yi Dong
Xin Yang
This paper describes a decarboxylative C-H carbenoid functionalization of (hetero)aryl carboxylic acids by using pyridotriazoles as the carbene precursors, which overcomes the limitation of ester group retention in conventional reactions, e...