Tumor-Targeted pan-RAS Inhibition as a Novel Biologic Therapy for Diffuse Midline Glioma [0.03%]
针对弥散内源性胶质瘤的靶向泛RAS抑制新型生物疗法
Stefanie-Grace Sbergio,Huazhu Liang,Lucy Chen et al.
Stefanie-Grace Sbergio et al.
Background: Pediatric high-grade gliomas (pHGG) are the leading cause of childhood cancer-related deaths. Those arising in the midline harboring a lysine to methionine substitution at position 27 in histone 3 (H3K27M), te...
Selective histone deacetylase inhibition as a therapeutically relevant strategy in H3K27M-glioma [0.03%]
选择性组蛋白去乙酰化酶抑制作用在H3K27M突变型胶质瘤中的治疗策略研究
Andrew Groves,Orville O Kirkland,Costanza Lo Cascio et al.
Andrew Groves et al.
Background: Diffuse midline glioma (DMG) is a lethal pediatric brain tumor, driven by profound epigenetic dysregulation, raising the possibility that targeting epigenetic regulators such as histone deacetylases (HDACs) co...
Gadolinium-Free MR Perfusion Imaging Based on Generative Adversarial Network for Primary Intracranial Tumor Diagnosis: A Multi-Center Study [0.03%]
基于生成对抗网络的无钆磁共振灌注成像在原发性颅内肿瘤诊断中的价值：多中心研究
Guoqi Lin,Wangbin Ding,Yihua Chen et al.
Guoqi Lin et al.
Background: Accurate evaluation of tumor vascularity is essential in neuro-oncology, but conventional cerebral blood volume (CBV) mapping depends on gadolinium-based contrast agents. The aim was to develop a gadolinium-fr...
A MYCN-GAL-SREBP1 Lipogenic Axis Drives Proliferation in Silent Corticotroph Adenomas [0.03%]
MYCN-GAL-SREBP1脂生成轴驱动静默促肾上腺皮质激素细胞腺瘤的增殖
Changxi Han,Junchen Wu,Jing Xie et al.
Changxi Han et al.
Background: Silent corticotroph adenomas (SCAs) are an aggressive pituitary neuroendocrine tumor (PitNET) subtype lacking effective medical therapies and showing a high rate of recurrence. The molecular mechanisms driving...
Ho-Keung Ng
Ho-Keung Ng
Tumor-associated epilepsy at diagnosis in glioblastoma patients reveals an inflammatory molecular signature and is associated with better overall survival [0.03%]
新诊断胶质母细胞瘤患者的肿瘤相关癫痫具有炎症分子特征并预示更好的总生存率
Lilyana Dimova,Jenny Stritzelberger,Diyan Dimov et al.
Lilyana Dimova et al.
Background: Glioblastoma (GB) is the most aggressive primary brain tumor in adults. Tumor-associated epilepsy at diagnosis (TAE) is common, yet its prognostic significance remains unclear. ...
Multi-sampling allows intra-tumoral heterogeneity querying and vulnerability profiling in glioblastoma [0.03%]
多重采样允许在胶质母细胞瘤中进行肿瘤内异质性查询和脆弱性分析
Diogo Moniz Garcia,Wan-Hsin Lin,Daniel P Wickland et al.
Diogo Moniz Garcia et al.
Background: Glioblastoma (GBM) remains a devastating cancer with limited treatment options, largely due to its heterogeneity. While supramaximal resection has recently provided survival benefits, therapeutic profiling of ...
BRAF-altered glioma in adults and children: A Society for Neuro-Oncology (SNO) and European Society for Neuro-Oncology (EANO) consensus review on clinical management and future directions [0.03%]
成人和儿童BRAF基因突变型胶质瘤的临床管理及未来发展方向共识意见（美国神经肿瘤学会和欧洲神经肿瘤学组）
Karisa C Schreck,Macarena I de la Fuente,Mary Jane Lim Fat et al.
Karisa C Schreck et al.
Oncogenic BRAF alterations occur in a subset of diffuse gliomas across WHO grades and are increasingly identified through modern molecular diagnostics. In addition to standard glioma therapies, targeted treatments are available for patients...